論文 - 詳細
| RRC ID | 1397 |
|---|---|
| 著者 | Takahashi T, Takasuka N, Iigo M, Baba M, Nishino H, Tsuda H, Okuyama T. |
| タイトル | Isoliquiritigenin, a flavonoid from licorice, reduces prostaglandin E2 and nitric oxide, causes apoptosis, and suppresses aberrant crypt foci development. |
| ジャーナル | Cancer Sci |
| Abstract |
Isoliquiritigenin (ILTG), a flavonoid group compound, exists in some foodstuffs and herbal medicines such as licorice (Glycyrrhiza uralensis Fisher). Previously, we showed that ILTG can suppress azoxymethane (AOM)-induced colon carcinogenesis in ddY mice. In the present report, we present evidence that ILTG markedly decreases both prostaglandin E2 (PGE2) and nitric oxide (NO) production in RAW264.7 mouse macrophage cells. The decrease of PGE2 was dependent on cyclooxygenase-2 (COX-2) expression and the decrease of NO appeared due to a decrease in inducible nitric oxide synthase (iNOS) protein expression. In mouse and human colon carcinoma cells, ILTG treatment suppressed cell growth and caused apoptosis. Furthermore, in vivo administration of ILTG inhibited the induction of preneoplastic aberrant crypt foci (ACF) in the male F344 rat colon. Our results suggest that ILTG is a promising chemopreventive agent against colon carcinogenesis. |
| 巻・号 | 95(5) |
| ページ | 448-53 |
| 公開日 | 2004-5-1 |
| DOI | 10.1111/j.1349-7006.2004.tb03230.x |
| PMID | 15132774 |
| MeSH | Aldehyde Reductase / antagonists & inhibitors Animals Apoptosis / drug effects* Carcinoma / pathology* Carcinoma / prevention & control Cell Culture Techniques Chalcone / analogs & derivatives* Chalcone / pharmacology* Chalcones Chemoprevention Colonic Neoplasms / pathology* Colonic Neoplasms / prevention & control Dinoprostone / analysis* Enzyme Inhibitors / pharmacology* Glycyrrhiza / chemistry* Humans Macrophages Male Mice Nitric Oxide / analysis* Rats Rats, Inbred F344 |
| IF | 4.966 |
| 引用数 | 138 |
| WOS 分野 | ONCOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | RAW 264(RCB0535) RCN-9(RCB0511) |