論文 - 詳細
| RRC ID | 1427 |
|---|---|
| 著者 | Iwano S, Nukaya M, Saito T, Asanuma F, Kamataki T. |
| タイトル | A possible mechanism for atherosclerosis induced by polycyclic aromatic hydrocarbons. |
| ジャーナル | Biochem Biophys Res Commun |
| Abstract |
Polycyclic aromatic hydrocarbons (PAHs), aryl hydrocarbon receptor (AHR) ligands, induce atherogenesis. Liver X receptor (LXR) alpha is known to be involved in the control of cholesterol homeostasis. Thus, the purpose of this study was to investigate the effects of 3-methlycholanthrene (MC), one of the PAHs, on LXRalpha-mediated signal transductions. We found that expression of mRNAs for ATP binding cassette A1, sterol regulatory element binding protein 1c (SREBP-1c), fatty acid synthase, and stearoyl-CoA desaturase was suppressed by treatment of HepG2 cells with MC. A luciferase reporter assay revealed that LXRalpha- and SREBP-1c-mediated transactivations were inhibited by MC via AHR. Based on these lines of evidence, we propose that down-regulation of the LXRalpha-regulated genes by PAHs is one of the causes responsible for atherosclerosis induced by PAHs. |
| 巻・号 | 335(1) |
| ページ | 220-6 |
| 公開日 | 2005-9-16 |
| DOI | 10.1016/j.bbrc.2005.07.062 |
| PII | S0006-291X(05)01541-X |
| PMID | 16061200 |
| MeSH | Arteriosclerosis / chemically induced* Arteriosclerosis / genetics Arteriosclerosis / metabolism Benz(a)Anthracenes / pharmacology Benz(a)Anthracenes / toxicity CCAAT-Enhancer-Binding Proteins / genetics CCAAT-Enhancer-Binding Proteins / metabolism Cell Line, Tumor DNA-Binding Proteins / genetics DNA-Binding Proteins / metabolism Gene Expression Regulation / drug effects Humans Liver X Receptors Models, Biological Orphan Nuclear Receptors Polycyclic Aromatic Hydrocarbons / pharmacology* Polycyclic Aromatic Hydrocarbons / toxicity RNA, Messenger / genetics RNA, Messenger / metabolism RNA, Small Interfering / genetics Receptors, Aryl Hydrocarbon / genetics Receptors, Aryl Hydrocarbon / metabolism Receptors, Cytoplasmic and Nuclear / genetics Sterol Regulatory Element Binding Protein 1 Transcription Factors / genetics Transcription Factors / metabolism Transcription, Genetic / drug effects Transcription, Genetic / genetics |
| IF | 2.985 |
| 引用数 | 20 |
| WOS 分野 | BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY |
| リソース情報 | |
| ヒト・動物細胞 | Hep G2 |