RRC ID 144
Author Nishihashi T, Trandafir CC, Wang A, Ji X, Kurahashi K.
Title Enhanced reactivity to vasopressin in rat basilar arteries during vasospasm after subarachnoid hemorrhage.
Journal Eur. J. Pharmacol.
Abstract Subarachnoid hemorrhage increases the plasma level of vasopressin, a well-known vasoconstrictor. We examined the sensitivity to vasopressin in rat basilar artery after subarachnoid hemorrhage using a rat subarachnoid hemorrhage model. Vasospasm was observed 1-2 days after subarachnoid hemorrhage induction, and the contractile response to vasopressin in rat basilar arteries was assessed. The concentration-response curve for vasopressin in subarachnoid hemorrhage (1 day) rats shifted leftward compared with that of control rats. The concentration-response curve for vasopressin V(1) receptor agonist also shifted leftward and upward compared with that of control rats. The concentration-response curve for vasopressin was inhibited not by vasopressin V(2) receptor antagonist but by vasopressin V(1) receptor antagonist. Thus, it was demonstrated that the vasoconstricting effect of vasopressin was significantly enhanced in the vasospasm phase after subarachnoid hemorrhage.
Volume 513(1-2)
Pages 93-100
Published 2005-4-18
DOI 10.1016/j.ejphar.2005.01.051
PII S0014-2999(05)00055-5
PMID 15878713
MeSH Animals Antidiuretic Hormone Receptor Antagonists Basilar Artery / drug effects* Basilar Artery / pathology Basilar Artery / physiopathology Dose-Response Relationship, Drug Endothelium, Vascular / physiology In Vitro Techniques Male Morpholines / pharmacology Oxytocin / analogs & derivatives* Oxytocin / pharmacology Potassium Chloride / pharmacology Rats Rats, Sprague-Dawley Receptors, Vasopressin / agonists Spiro Compounds / pharmacology Subarachnoid Hemorrhage / complications* Time Factors Vasoconstriction / drug effects* Vasoconstrictor Agents / pharmacology* Vasopressins / blood Vasopressins / pharmacology* Vasospasm, Intracranial / etiology Vasospasm, Intracranial / physiopathology*
IF 3.04
Times Cited 13
WOS Category PHARMACOLOGY & PHARMACY
Resource
Rats