RRC ID |
1442
|
著者 |
Innami S, Ishida H, Nakamura K, Kondo M, Tabata K, Koguchi T, Shimizu J, Furusho T.
|
タイトル |
Jew's mellow leaves (Corchorus olitorius) suppress elevation of postprandial blood glucose levels in rats and humans.
|
ジャーナル |
Int J Vitam Nutr Res
|
Abstract |
The study was performed to explore the suppressive effect of Jew's mellow leaves (JML) on postprandial blood glucose levels in rats and humans. A soluble dietary fiber (SDF) was extracted from the freeze-dried JML powder. An elevation of the postprandial blood glucose level in rats given 1% or 2% JML-SDF solution orally together with 20% glucose solution was significantly suppressed as compared with that observed in the control rats given only glucose solution. When seven healthy young male adults ingested 225 mL of JML mixed juice containing 15 g of freeze-dried powder with 75 g of glucose in the fasting state in the morning, the elevation of the postprandial blood glucose level was significantly suppressed as compared with the control subjects. The diffusion rate of glucose and the permeation rate of glucose in the cultured Caco-2 cells were both significantly reduced by the addition of appropriate amounts of JML-SDF when compared to the controls. These results indicate that the effective substance in JML for suppressing blood glucose elevation is a kind of mucilaginous SDF. The mechanism by which this suppression occurs may be largely attributable to the delayed absorption of glucose from the intestinal membrane in the upper digestive tract by viscous SDF.
|
巻・号 |
75(1)
|
ページ |
39-46
|
公開日 |
2005-1-1
|
DOI |
10.1024/0300-9831.75.1.39
|
PMID |
15830920
|
MeSH |
Adult
Analysis of Variance
Animals
Blood Glucose / drug effects*
Cells, Cultured
Corchorus* / chemistry
Dietary Fiber / pharmacology*
Dose-Response Relationship, Drug
Freeze Drying / methods
Glucose / administration & dosage
Glucose / pharmacokinetics
Glucose Solution, Hypertonic / administration & dosage
Humans
In Vitro Techniques
Male
Plant Leaves / chemistry
Plant Preparations / chemistry
Plant Preparations / pharmacology*
Postprandial Period / drug effects*
Rats
Rats, Sprague-Dawley
Reference Values
Time Factors
Viscosity
|
IF |
0.765
|
引用数 |
5
|
WOS 分野
|
NUTRITION & DIETETICS
|
リソース情報 |
ヒト・動物細胞 |
CACO-2(RCB0988) |