論文 - 詳細
| RRC ID | 1443 |
|---|---|
| 著者 | Miharada K, Hiroyama T, Sudo K, Nagasawa T, Nakamura Y. |
| タイトル | Lipocalin 2 functions as a negative regulator of red blood cell production in an autocrine fashion. |
| ジャーナル | FASEB J |
| Abstract |
Members of the lipocalin protein family are typically small, secreted proteins that possess a variety of functions. Although the physiological role of lipocalin 2 remains to be fully elucidated, a few pivotal functions have recently been reported, e.g., regulation of the apoptosis of leukocytes. Unexpectedly, lipocalin 2 is abundantly expressed in erythroid progenitor cells. An in vitro culture experiment demonstrated that lipocalin 2 induces apoptosis and inhibits differentiation of erythroid progenitor cells. During acute anemia the expression of lipocalin 2 was reduced in erythroid cells by a feedback system. Furthermore, injection of recombinant lipocalin 2 into mice suffering from acute anemia retarded the recovery of red blood cell (RBC) numbers, suggesting the importance of reduced expression of lipocalin 2 for the efficient recovery of RBC numbers. These results indicate that lipocalin 2 suppresses RBC production in an autocrine fashion. Hence, anemia arising from pathological conditions, such as chronic inflammation, might be partly due to increased levels of lipocalin 2 secreted from expanded leukocytes and/or macrophages. Also, anemia arising from malignancies might be partly due to the abundant secretion of lipocalin 2 from tumor cells. Thus, lipocalin 2 may represent an attractive therapeutic target for anemia under certain pathological conditions. |
| 巻・号 | 19(13) |
| ページ | 1881-3 |
| 公開日 | 2005-11-1 |
| DOI | 10.1096/fj.05-3809fje |
| PII | 05-3809fje |
| PMID | 16157692 |
| MeSH | Acute-Phase Proteins / physiology* Animals Annexin A5 / chemistry Antigens, CD / biosynthesis Apoptosis Blotting, Western Bone Marrow Cells / cytology Caspases / metabolism Cell Culture Techniques Cell Differentiation Cell Lineage Cell Separation Cell Survival Enzyme Activation Enzyme-Linked Immunosorbent Assay Erythrocytes / cytology* Erythrocytes / metabolism Female Flow Cytometry Immunoblotting Interleukin-3 / metabolism Leukocytes / cytology Leukocytes, Mononuclear / cytology Lipocalin-2 Lipocalins Macrophages / cytology Mice Mice, Inbred C57BL Models, Biological Models, Statistical Oncogene Proteins / physiology* RNA, Messenger / metabolism Receptors, Transferrin / biosynthesis Recombinant Proteins / chemistry Reverse Transcriptase Polymerase Chain Reaction Spleen / metabolism Stem Cells / cytology Tissue Distribution |
| IF | 4.966 |
| 引用数 | 54 |
| WOS 分野 | BIOLOGY BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | 10T1/2(RCB0247) |