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Species Resource Title
Mice RBRC01390 The histone demethylase Phf2 acts as a molecular checkpoint to prevent NAFLD progression during obesity.
Mice RBRC03899 Proper closure of the optic fissure requires ephrin A5-EphB2-JNK signaling.
Yeast Shugoshin holds the potential to inhibit APC/C and thereby prevents separase activation.
Human and Animal Cells HeLa(RCB0007) , 293(RCB1637) Spatiotemporal regulation of MKK4 dictates switch-like JNK activation and binary cell-fate decisions.
Human and Animal Cells A549(RCB3677) Cell cycle dependence of ERK activation dynamics is regulated by PI3K and PAK1 signaling.
Arabidopsis / Cultured plant cells, genes pda03090 Structural determinants for pH-dependent activation of a plant metacaspase.
Human and Animal Cells HeLa Mammalian target of differentiation-inducing factor-1 is mitochondrial malate dehydrogenase for activation of AMP-activated protein kinase and induction of mitochondrial fission.
Drosophila DGRC#119567 Activation of the innate immunity in Drosophila by endogenous chromosomal DNA that escaped apoptotic degradation.
Drosophila DGRC#119558 Control of the cell death pathway by Dapaf-1, a Drosophila Apaf-1/CED-4-related caspase activator.
Drosophila DGRC#119557 Proapoptotic activity of Caenorhabditis elegans CED-4 protein in Drosophila: implicated mechanisms for caspase activation.
Drosophila DGRC#206596 , 5520R-3 Gp93 inhibits unfolded protein response-mediated c-Jun N-terminal kinase activation and cell invasion.
DNA material pCAG-HIVgp (RDB04394) , pCMV-VSV-G-RSV-Rev (RDB04393) Chloride intracellular channel protein 2 is secreted and inhibits MMP14 activity, while preventing tumor cell invasion and metastasis.
Human and Animal Cells HeLa(RCB0007) , 293T(RCB2202) Regulation of CCR4-NOT complex deadenylase activity and cellular responses by MK2-dependent phosphorylation of CNOT2.
Human and Animal Cells HOS(RCB0992) , 293T(RCB2202) , Saos-2(RCB3688) , A549(RCB0098) PP2A inhibitor SET promotes mTORC1 and Bmi1 signaling through Akt activation and maintains the colony-formation ability of cancer cells.
Human and Animal Cells SK-MEL-28(RCB1930) Depolarization potentiates TRAIL-induced apoptosis in human melanoma cells: role for ATP-sensitive K+ channels and endoplasmic reticulum stress.
DNA material EGFP-hEFA6A (RDB20108) , EGFP-hEFA6B (RDB20109) , EGFP-hEFA6C (RDB20110) EFA6 activates Arf6 and participates in its targeting to the Flemming body during cytokinesis.
Human and Animal Cells THP-1(RCB1189) The lysosome rupture-activated TAK1-JNK pathway regulates NLRP3 inflammasome activation.
C.elegans tm4525 Proteasome activity contributes to pro-survival response upon mild mitochondrial stress in Caenorhabditis elegans.
C.elegans tm6369 Loss of SET1/COMPASS methyltransferase activity reduces lifespan and fertility in Caenorhabditis elegans.
Human and Animal Cells HS-Sch-2(RCB2230) , HS-PSS(RCB2362) , YST-1(RCB2136) Prognostic significance of AKT/mTOR and MAPK pathways and antitumor effect of mTOR inhibitor in NF1-related and sporadic malignant peripheral nerve sheath tumors.