論文 - 詳細
| RRC ID | 1476 |
|---|---|
| 著者 | Nakanishi K, Sudo T, Morishima N. |
| タイトル | Endoplasmic reticulum stress signaling transmitted by ATF6 mediates apoptosis during muscle development. |
| ジャーナル | J Cell Biol |
| Abstract |
Although apoptosis occurs during myogenesis, its mechanism of initiation remains unknown. In a culture model, we demonstrate activation of caspase-12, the initiator of the endoplasmic reticulum (ER) stress-specific caspase cascade, during apoptosis associated with myoblast differentiation. Induction of ER stress-responsive proteins (BiP and CHOP) was also observed in both apoptotic and differentiating cells. ATF6, but not other ER stress sensors, was specifically activated during apoptosis in myoblasts, suggesting that partial but selective activation of ER stress signaling was sufficient for induction of apoptosis. Activation of caspase-12 was also detected in developing muscle of mouse embryos and gradually disappeared later. CHOP was also transiently induced. These results suggest that specific ER stress signaling transmitted by ATF6 leads to naturally occurring apoptosis during muscle development. |
| 巻・号 | 169(4) |
| ページ | 555-60 |
| 公開日 | 2005-5-23 |
| DOI | 10.1083/jcb.200412024 |
| PII | jcb.200412024 |
| PMID | 15897261 |
| PMC | PMC2171703 |
| MeSH | Activating Transcription Factor 6 Animals Apoptosis / physiology* CCAAT-Enhancer-Binding Proteins / metabolism Caspase 12 Caspases / metabolism Cell Differentiation / physiology* Cell Line DNA-Binding Proteins / metabolism* Endoplasmic Reticulum / metabolism* Endoplasmic Reticulum Chaperone BiP Heat-Shock Proteins / metabolism Mice Molecular Chaperones / metabolism Muscle, Skeletal / cytology Muscle, Skeletal / growth & development Muscle, Skeletal / metabolism* Myoblasts / cytology Myoblasts / metabolism Signal Transduction / physiology Stress, Physiological / metabolism* Transcription Factor CHOP Transcription Factors / metabolism* |
| IF | 8.811 |
| 引用数 | 124 |
| WOS 分野 | CELL BIOLOGY |
| リソース情報 | |
| ヒト・動物細胞 | C2C12(RCB0987) |