Reference - Detail
| RRC ID | 1519 |
|---|---|
| Author | Akimoto T, Ushida T, Miyaki S, Akaogi H, Tsuchiya K, Yan Z, Williams RS, Tateishi T. |
| Title | Mechanical stretch inhibits myoblast-to-adipocyte differentiation through Wnt signaling. |
| Journal | Biochem Biophys Res Commun |
| Abstract |
Myoblasts are able to differentiate into other mesenchymal lineages including adipocytes and osteoblasts. However, it is not known how this differentiation is normally regulated in intact animals and humans. Here, we subjected cultured C2C12 myoblasts to cyclic mechanical stretch (20% elongation) during differentiation into adipocytes. Mechanical stretch inhibited the myoblast-to-adipocyte differentiation significantly, concurrent with an enhanced expression of Wnt10b mRNA. Inhibition of the Wnt signaling by incubation of the myoblasts with a soluble Wnt ligand, sFRP-2, abolished the inhibitory function of mechanical stretch on adipogenesis. These findings provide evidence that mechanical stretch inhibits myoblast-to-adipocyte differentiation possibly through Wnt signaling. |
| Volume | 329(1) |
| Pages | 381-5 |
| Published | 2005-4-1 |
| DOI | 10.1016/j.bbrc.2005.01.136 |
| PII | S0006-291X(05)00122-1 |
| PMID | 15721317 |
| MeSH | Adipocytes / cytology* Adipocytes / metabolism Animals Azo Compounds / pharmacology Cell Differentiation Cell Line Cell Lineage Cell Membrane / metabolism Intercellular Signaling Peptides and Proteins / metabolism* Ligands Mice Myoblasts / cytology* RNA / metabolism RNA, Messenger / metabolism Reverse Transcriptase Polymerase Chain Reaction Signal Transduction Stress, Mechanical Wnt Proteins |
| IF | 2.985 |
| Times Cited | 47 |
| WOS Category | BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY |
| Altmetric score |
オルトメトリクス指標項目
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| Total number of mentions | 0 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | C2C12(RCB0987) |