Reference - Detail
| RRC ID | 15377 |
|---|---|
| Author | Slováková J, Carmena A. |
| Title | Canoe functions at the CNS midline glia in a complex with Shotgun and Wrapper-Nrx-IV during neuron-glia interactions. |
| Journal | Development |
| Abstract |
Vertebrates and insects alike use glial cells as intermediate targets to guide growing axons. Similar to vertebrate oligodendrocytes, Drosophila midline glia ensheath and separate axonal commissures. Neuron-glia interactions are crucial during these events, although the proteins involved remain largely unknown. Here, we show that Canoe (Cno), the Drosophila ortholog of AF-6, and the DE-cadherin Shotgun (Shg) are highly restricted to the interface between midline glia and commissural axons. cno mutant analysis, genetic interactions and co-immunoprecipitation assays unveil Cno function as a novel regulator of neuron-glia interactions, forming a complex with Shg, Wrapper and Neurexin IV, the homolog of vertebrate Caspr/paranodin. Our results also support additional functions of Cno, independent of adherens junctions, as a regulator of adhesion and signaling events in non-epithelial tissues. |
| Volume | 138(8) |
| Pages | 1563-71 |
| Published | 2011-4-1 |
| DOI | 10.1242/dev.056192 |
| PII | dev.056192 |
| PMID | 21389054 |
| MeSH | Animals Cadherins / metabolism* Cell Adhesion Molecules, Neuronal / metabolism* Central Nervous System / cytology Central Nervous System / metabolism* Drosophila Drosophila Proteins / genetics Drosophila Proteins / metabolism* Fluorescent Antibody Technique Immunohistochemistry Immunoprecipitation Nerve Tissue Proteins / metabolism* Neuroglia / metabolism* Neurons / metabolism* Protein Binding |
| IF | 5.611 |
| Times Cited | 11 |
| WOS Category | DEVELOPMENTAL BIOLOGY |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Bluesky |
| Total number of mentions | 2 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Drosophila | Df(3R)ED5147 (DGRC#150143) |