RRC ID 15390
著者 Benchabane H, Xin N, Tian A, Hafler BP, Nguyen K, Ahmed A, Ahmed Y.
タイトル Jerky/Earthbound facilitates cell-specific Wnt/Wingless signalling by modulating β-catenin-TCF activity.
ジャーナル EMBO J
Abstract Wnt/Wingless signal transduction directs fundamental developmental processes, and upon hyperactivation triggers colorectal adenoma/carcinoma formation. Responses to Wnt stimulation are cell specific and diverse; yet, how cell context modulates Wnt signalling outcome remains obscure. In a Drosophila genetic screen for components that promote Wingless signalling, we identified Earthbound 1 (Ebd1), a novel member in a protein family containing Centromere Binding Protein B (CENPB)-type DNA binding domains. Ebd1 is expressed in only a subset of Wingless responsive cell types, and is required for only a limited number of Wingless-dependent processes. In addition, Ebd1 shares sequence similarity and can be functionally replaced with the human CENPB domain protein Jerky, previously implicated in juvenile myoclonic epilepsy development. Both Jerky and Ebd1 interact directly with the Wnt/Wingless pathway transcriptional co-activators β-catenin/Armadillo and T-cell factor (TCF). In colon carcinoma cells, Jerky facilitates Wnt signalling by promoting association of β-catenin with TCF and recruitment of β-catenin to chromatin. These findings indicate that tissue-restricted transcriptional co-activators facilitate cell-specific Wnt/Wingless signalling responses by modulating β-catenin-TCF activity.
巻・号 30(8)
ページ 1444-58
公開日 2011-4-20
DOI 10.1038/emboj.2011.67
PII emboj201167
PMID 21399610
PMC PMC3102276
MeSH Animals Apc1 Subunit, Anaphase-Promoting Complex-Cyclosome Blotting, Western Cells, Cultured Centromere Protein B / genetics Centromere Protein B / metabolism* Colonic Neoplasms / genetics Colonic Neoplasms / metabolism DNA-Binding Proteins Drosophila / genetics Drosophila / growth & development Drosophila / metabolism* Drosophila Proteins / genetics Drosophila Proteins / metabolism* Drosophila Proteins / physiology Humans Immunoenzyme Techniques Immunoprecipitation Kidney / cytology Kidney / metabolism Luciferases / metabolism Nuclear Proteins / genetics Nuclear Proteins / metabolism* Protein Binding RNA, Messenger / genetics RNA-Binding Proteins Reverse Transcriptase Polymerase Chain Reaction Signal Transduction TCF Transcription Factors / genetics TCF Transcription Factors / metabolism* Trans-Activators / genetics Trans-Activators / metabolism* Wnt Proteins / genetics Wnt Proteins / metabolism* Wnt1 Protein / genetics Wnt1 Protein / metabolism* beta Catenin / genetics beta Catenin / metabolism*
IF 9.889
引用数 22
WOS 分野 BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY
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