論文 - 詳細
| RRC ID | 15404 |
|---|---|
| 著者 | Taniguchi K, Maeda R, Ando T, Okumura T, Nakazawa N, Hatori R, Nakamura M, Hozumi S, Fujiwara H, Matsuno K. |
| タイトル | Chirality in planar cell shape contributes to left-right asymmetric epithelial morphogenesis. |
| ジャーナル | Science |
| Abstract |
Some organs in animals display left-right (LR) asymmetry. To better understand LR asymmetric morphogenesis in Drosophila, we studied LR directional rotation of the hindgut epithelial tube. Hindgut epithelial cells adopt a LR asymmetric (chiral) cell shape within their plane, and we refer to this cell behavior as planar cell-shape chirality (PCC). Drosophila E-cadherin (DE-Cad) is distributed to cell boundaries with LR asymmetry, which is responsible for the PCC formation. Myosin ID switches the LR polarity found in PCC and in DE-Cad distribution, which coincides with the direction of rotation. An in silico simulation showed that PCC is sufficient to induce the directional rotation of this tissue. Thus, the intrinsic chirality of epithelial cells in vivo is an underlying mechanism for LR asymmetric tissue morphogenesis. |
| 巻・号 | 333(6040) |
| ページ | 339-41 |
| 公開日 | 2011-7-15 |
| DOI | 10.1126/science.1200940 |
| PII | 333/6040/339 |
| PMID | 21764746 |
| MeSH | Adherens Junctions Animals Body Patterning Cadherins / metabolism* Cell Polarity Cell Shape* Computer Simulation Drosophila / cytology Drosophila / embryology* Drosophila / genetics Drosophila Proteins / genetics Drosophila Proteins / metabolism* Epithelial Cells / cytology* Intestines / cytology Intestines / embryology Models, Biological Morphogenesis Myosin Type I / genetics Myosin Type I / metabolism* Rotation |
| IF | 41.846 |
| 引用数 | 108 |
| WOS 分野 | CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | the Drosophila Genetic Resource Center at Kyoto Institute of Technology for flies |