Reference - Detail
RRC ID | 15414 |
---|---|
Author | Ogata M, Oka K, Seki M, Hoshi M, Takatsu H, Mashino T, Urano S, Endo T. |
Title | Solubilization of dipropofol, an antibacterial agent, using saccharide and ascorbic acid. |
Journal | Biol Pharm Bull |
Abstract |
Dipropofol has a strong antibacterial activity against Gram-positive bacteria. However, it lacked the solubility in water and this property was supposed to limit its efficacy. We tried to improve the solubility and found a new solubilization method of dipropofol in water by the addition of a monosaccharide or ascorbic acid. |
Volume | 30(8) |
Pages | 1565-8 |
Published | 2007-8-1 |
DOI | 10.1248/bpb.30.1565 |
PII | JST.JSTAGE/bpb/30.1565 |
PMID | 17666822 |
MeSH | Alkanes / chemistry* Alkanes / pharmacology Anti-Bacterial Agents / chemistry* Anti-Bacterial Agents / pharmacology Ascorbic Acid / chemistry Drug Synergism Escherichia coli / drug effects Excipients Microbial Sensitivity Tests Monosaccharides / chemistry* Oxidation-Reduction Phenols / chemistry* Phenols / pharmacology Solubility Staphylococcus aureus / drug effects |
IF | 1.863 |
Times Cited | 4 |
WOS Category | PHARMACOLOGY & PHARMACY |
Resource | |
General Microbes | JCM 5491 |