論文 - 詳細
| RRC ID | 15414 |
|---|---|
| 著者 | Ogata M, Oka K, Seki M, Hoshi M, Takatsu H, Mashino T, Urano S, Endo T. |
| タイトル | Solubilization of dipropofol, an antibacterial agent, using saccharide and ascorbic acid. |
| ジャーナル | Biol Pharm Bull |
| Abstract |
Dipropofol has a strong antibacterial activity against Gram-positive bacteria. However, it lacked the solubility in water and this property was supposed to limit its efficacy. We tried to improve the solubility and found a new solubilization method of dipropofol in water by the addition of a monosaccharide or ascorbic acid. |
| 巻・号 | 30(8) |
| ページ | 1565-8 |
| 公開日 | 2007-8-1 |
| DOI | 10.1248/bpb.30.1565 |
| PII | JST.JSTAGE/bpb/30.1565 |
| PMID | 17666822 |
| MeSH | Alkanes / chemistry* Alkanes / pharmacology Anti-Bacterial Agents / chemistry* Anti-Bacterial Agents / pharmacology Ascorbic Acid / chemistry Drug Synergism Escherichia coli / drug effects Excipients Microbial Sensitivity Tests Monosaccharides / chemistry* Oxidation-Reduction Phenols / chemistry* Phenols / pharmacology Solubility Staphylococcus aureus / drug effects |
| IF | 1.863 |
| 引用数 | 4 |
| WOS 分野 | PHARMACOLOGY & PHARMACY |
| リソース情報 | |
| 一般微生物 | JCM 5491 |