| RRC ID |
15431
|
| 著者 |
Kawano K, Ebisawa M, Hase K, Fukuda S, Hijikata A, Kawano S, Date Y, Tsuneda S, Itoh K, Ohno H.
|
| タイトル |
Psg18 is specifically expressed in follicle-associated epithelium.
|
| ジャーナル |
Cell Struct Funct
|
| Abstract |
Pregnancy-specific glycoproteins (Psgs) secreted by the placenta regulate the immune system to ensure the survival of the fetal allograft by inducing IL-10, an anti-inflammatory cytokine. However, it is unknown whether Psgs are involved in more general aspects of immune response other than maternal immunity. Here, we report that Psg18 is highly expressed in the follicle-associated epithelium (FAE) overlaying Peyer's patches (PPs). Bioinformatics analysis with Reference Database for Immune Cells (RefDIC) as well as RT-PCR data demonstrated that Psg18 is exclusively expressed in FAE in adult mice, in contrast to other Psg family members that are either not expressed or only slightly expressed in FAE. Psg18 expression was observed in FAE of germ-free-conditioned mice, and was slightly upregulated after bacterial inoculation. In situ hybridization analysis revealed that Psg18 is widely expressed throughout FAE. Furthermore, Psg18 protein is deposited on the extracellular matrix in the subepithelial dome beneath FAE, where antigen-presenting cells accumulate. These results suggest that Psg18 is an FAE-specific marker protein that could promote interplay between FAE and immune cells in mucosa-associated lymphoid tissues.
|
| 巻・号 |
32(2)
|
| ページ |
115-26
|
| 公開日 |
2007-1-1
|
| DOI |
10.1247/csf.07014
|
| PII |
JST.JSTAGE/csf/07014
|
| PMID |
17984568
|
| MeSH |
Animals
Computational Biology
Epithelial Cells / immunology
Epithelial Cells / metabolism*
Extracellular Matrix / genetics
Female
Gene Expression Profiling*
Humans
In Situ Hybridization
Male
Mice
Oligonucleotide Array Sequence Analysis
Organ Specificity
Ovarian Follicle / cytology
Ovarian Follicle / metabolism*
Peyer's Patches / cytology
Pregnancy
Pregnancy Proteins / genetics
Pregnancy Proteins / immunology
Pregnancy Proteins / metabolism*
Protein Transport
RNA Transport
RNA, Messenger / genetics
RNA, Messenger / metabolism
Reverse Transcriptase Polymerase Chain Reaction
Up-Regulation
|
| IF |
2.429
|
| 引用数 |
10
|
|
WOS 分野
|
CELL BIOLOGY
|
| リソース情報 |
| 一般微生物 |
JCM 1254 |
