論文 - 詳細
| RRC ID | 15534 |
|---|---|
| 著者 | Luo W, Sehgal A. |
| タイトル | Regulation of circadian behavioral output via a MicroRNA-JAK/STAT circuit. |
| ジャーナル | Cell |
| Abstract |
Although molecular components of the circadian clock are known, mechanisms that transmit signals from the clock and produce rhythmic behavior are poorly understood. We find that the microRNA miR-279 regulates the JAK/STAT pathway to drive rest:activity rhythms in Drosophila. Overexpression of microRNA miR-279 or miR-279 deletion attenuates rest:activity rhythms. Oscillations of the clock protein PERIOD are normal in pacemaker neurons lacking miR-279, suggesting that miR-279 acts downstream of the clock. We identify the JAK/STAT ligand, Upd, as a target of miR-279 and show that knockdown of Upd rescues the behavioral phenotype of miR-279 mutants. Manipulations of the JAK/STAT pathway also disrupt circadian rhythms. In addition, central clock neurons project in the vicinity of Upd-expressing neurons, providing a possible physical connection by which the central clock could regulate JAK/STAT signaling to control rest:activity rhythms. |
| 巻・号 | 148(4) |
| ページ | 765-79 |
| 公開日 | 2012-2-17 |
| DOI | 10.1016/j.cell.2011.12.024 |
| PII | S0092-8674(12)00011-6 |
| PMID | 22305007 |
| PMC | PMC3307393 |
| MeSH | Animals Behavior, Animal Biological Clocks Circadian Rhythm* Drosophila Proteins / metabolism* Drosophila melanogaster / physiology* Janus Kinases / metabolism MicroRNAs / genetics MicroRNAs / metabolism* Neurons / metabolism STAT Transcription Factors / metabolism Signal Transduction* Transcription Factors / metabolism* |
| IF | 38.637 |
| 引用数 | 88 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 5 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | |