Reference - Detail
| RRC ID | 15573 |
|---|---|
| Author | Mukherjee T, Kim WS, Mandal L, Banerjee U. |
| Title | Interaction between Notch and Hif-alpha in development and survival of Drosophila blood cells. |
| Journal | Science |
| Abstract |
A blood cell type termed crystal cell in Drosophila functions in clotting and wound healing and requires Notch for specification and maintenance. We report that crystal cells express elevated levels of Sima protein orthologous to mammalian hypoxia-inducible factor-α (Hif-α) even under conditions of normal oxygen availability. In these platelet-like crystal cells, Sima activates full-length Notch receptor signaling via a noncanonical, ligand-independent mechanism that promotes hemocyte survival during both normal hematopoietic development and hypoxic stress. This interaction initiates in early endosomes, is independent of Hif-β (Τangο in Drosophila), and does not activate hypoxia response targets. Studies in vertebrate myeloid cells have shown a similar up-regulation of Hif-α protein in well-oxygenated environments. This study provides a mechanistic paradigm for Hif-α/Notch interaction that may be conserved in mammals. |
| Volume | 332(6034) |
| Pages | 1210-3 |
| Published | 2011-6-3 |
| DOI | 10.1126/science.1199643 |
| PII | 332/6034/1210 |
| PMID | 21636775 |
| PMC | PMC4412745 |
| MeSH | Animals Aryl Hydrocarbon Receptor Nuclear Translocator / chemistry Aryl Hydrocarbon Receptor Nuclear Translocator / genetics Aryl Hydrocarbon Receptor Nuclear Translocator / metabolism Calcium-Binding Proteins / metabolism Cell Hypoxia Cell Survival Cytoplasmic Vesicles / metabolism DNA-Binding Proteins / chemistry DNA-Binding Proteins / genetics DNA-Binding Proteins / metabolism* Drosophila / cytology* Drosophila / genetics Drosophila / metabolism Drosophila Proteins / chemistry Drosophila Proteins / genetics Drosophila Proteins / metabolism* Endocytosis Hematopoiesis Hemocytes / cytology* Hemocytes / physiology* Hypoxia-Inducible Factor 1, alpha Subunit / metabolism Intercellular Signaling Peptides and Proteins / metabolism Jagged-1 Protein Ligands Membrane Proteins / metabolism Receptors, Notch / metabolism* Serrate-Jagged Proteins Signal Transduction Stress, Physiological |
| IF | 41.846 |
| Times Cited | 105 |
| WOS Category | CELL BIOLOGY |
| Resource | |
| Drosophila | 6713R-1 6713R-3 |