論文 - 詳細
| RRC ID | 15584 |
|---|---|
| 著者 | Copf T, Goguel V, Lampin-Saint-Amaux A, Scaplehorn N, Preat T. |
| タイトル | Cytokine signaling through the JAK/STAT pathway is required for long-term memory in Drosophila. |
| ジャーナル | Proc Natl Acad Sci U S A |
| Abstract |
Cytokine signaling through the JAK/STAT pathway regulates multiple cellular responses, including cell survival, differentiation, and motility. Although significant attention has been focused on the role of cytokines during inflammation and immunity, it has become clear that they are also implicated in normal brain function. However, because of the large number of different genes encoding cytokines and their receptors in mammals, the precise role of cytokines in brain physiology has been difficult to decipher. Here, we took advantage of Drosophila's being a genetically simpler model system to address the function of cytokines in memory formation. Expression analysis showed that the cytokine Upd is enriched in the Drosophila memory center, the mushroom bodies. Using tissue- and adult-specific expression of RNAi and dominant-negative proteins, we show that not only is Upd specifically required in the mushroom bodies for olfactory aversive long-term memory but the Upd receptor Dome, as well as the Drosophila JAK and STAT homologs Hop and Stat92E, are also required, while being dispensable for less stable memory forms. |
| 巻・号 | 108(19) |
| ページ | 8059-64 |
| 公開日 | 2011-5-10 |
| DOI | 10.1073/pnas.1012919108 |
| PII | 1012919108 |
| PMID | 21518857 |
| PMC | PMC3093528 |
| MeSH | Animals Animals, Genetically Modified Base Sequence Cytokines / antagonists & inhibitors Cytokines / genetics Cytokines / physiology* DNA Primers / genetics Drosophila / genetics Drosophila / physiology* Drosophila Proteins / antagonists & inhibitors Drosophila Proteins / genetics Drosophila Proteins / physiology* Gene Knockdown Techniques Genes, Insect Janus Kinases / antagonists & inhibitors Janus Kinases / genetics Janus Kinases / physiology* Memory, Long-Term / physiology* Mushroom Bodies / physiology RNA Interference Receptors, Interleukin / antagonists & inhibitors Receptors, Interleukin / genetics Receptors, Interleukin / physiology STAT Transcription Factors / antagonists & inhibitors STAT Transcription Factors / genetics STAT Transcription Factors / physiology* Signal Transduction / genetics Signal Transduction / physiology Smell / physiology Transcription Factors / antagonists & inhibitors Transcription Factors / genetics Transcription Factors / physiology* |
| IF | 9.412 |
| 引用数 | 31 |
| WOS 分野 | CELL BIOLOGY |
| リソース情報 | |
| ショウジョウバエ | 5993R-1 UAS-statRNAi1 |