論文 - 詳細
| RRC ID | 15603 |
|---|---|
| 著者 | Santos F, Wegkamp A, de Vos WM, Smid EJ, Hugenholtz J. |
| タイトル | High-Level folate production in fermented foods by the B12 producer Lactobacillus reuteri JCM1112. |
| ジャーナル | Appl Environ Microbiol |
| Abstract |
We observed that Lactobacillus reuteri JCM1112 produces B(12) and folate. However, the folate/B(12) mass ratio found was far below that desired for human consumption ( approximately 170:1). We used metabolic engineering applying genetic and physiological approaches to improve this ratio and developed a generic and natural process that significantly increases folate production. |
| 巻・号 | 74(10) |
| ページ | 3291-4 |
| 公開日 | 2008-5-1 |
| DOI | 10.1128/AEM.02719-07 |
| PII | AEM.02719-07 |
| PMID | 18344331 |
| PMC | PMC2394963 |
| MeSH | Biomass Folic Acid / biosynthesis* Food Microbiology* Lactobacillus reuteri / genetics Lactobacillus reuteri / metabolism* Metabolic Networks and Pathways / genetics* Models, Biological Vitamin B 12 / biosynthesis |
| IF | 4.016 |
| 引用数 | 72 |
| WOS 分野 | BIOTECHNOLOGY & APPLIED MICROBIOLOGY MICROBIOLOGY |
| リソース情報 | |
| 一般微生物 | JCM1112 |