| RRC ID |
15611
|
| Author |
Komaki N, Watanabe T, Ogasawara A, Sato N, Mikami T, Matsumoto T.
|
| Title |
Antifungal mechanism of hinokitiol against Candida albicans.
|
| Journal |
Biol Pharm Bull
|
| Abstract |
The growth of Candida albicans was dose-dependently inhibited by addition of hinokitiol. The sensitivity of C. albicans to hinokitiol under aerobic conditions was higher than that under anaerobic conditions. Amount of ATP in C. albicans was not inhibited by hinokitiol under both conditions. The expression of mRNAs related to the growth signal, CYR1 and RAS1, was inhibited by hinokitiol. These findings suggested that the growth inhibition of C. albicans by hinokitiol was due to the interruption of RAS-signal transmission, such as the cAMP pathway.
|
| Volume |
31(4)
|
| Pages |
735-7
|
| Published |
2008-4-1
|
| DOI |
10.1248/bpb.31.735
|
| PII |
JST.JSTAGE/bpb/31.735
|
| PMID |
18379073
|
| MeSH |
Adenosine Triphosphate / metabolism
Aerobiosis
Antifungal Agents / pharmacology*
Candida albicans / drug effects*
Candida albicans / growth & development
Candida albicans / metabolism
Indicators and Reagents
Microbial Sensitivity Tests
Monoterpenes / pharmacology*
RNA, Fungal / biosynthesis
RNA, Fungal / genetics
RNA, Messenger / biosynthesis
RNA, Messenger / genetics
Signal Transduction / drug effects
Tropolone / analogs & derivatives*
Tropolone / pharmacology
|
| IF |
1.863
|
| Times Cited |
25
|
|
WOS Category
|
PHARMACOLOGY & PHARMACY
|
| Resource |
| General Microbes |
JCM 1542
JCM 2074
JCM 2076 |
