Reference - Detail
| RRC ID | 15611 |
|---|---|
| Author | Komaki N, Watanabe T, Ogasawara A, Sato N, Mikami T, Matsumoto T. |
| Title | Antifungal mechanism of hinokitiol against Candida albicans. |
| Journal | Biol Pharm Bull |
| Abstract |
The growth of Candida albicans was dose-dependently inhibited by addition of hinokitiol. The sensitivity of C. albicans to hinokitiol under aerobic conditions was higher than that under anaerobic conditions. Amount of ATP in C. albicans was not inhibited by hinokitiol under both conditions. The expression of mRNAs related to the growth signal, CYR1 and RAS1, was inhibited by hinokitiol. These findings suggested that the growth inhibition of C. albicans by hinokitiol was due to the interruption of RAS-signal transmission, such as the cAMP pathway. |
| Volume | 31(4) |
| Pages | 735-7 |
| Published | 2008-4-1 |
| DOI | 10.1248/bpb.31.735 |
| PII | JST.JSTAGE/bpb/31.735 |
| PMID | 18379073 |
| MeSH | Adenosine Triphosphate / metabolism Aerobiosis Antifungal Agents / pharmacology* Candida albicans / drug effects* Candida albicans / growth & development Candida albicans / metabolism Indicators and Reagents Microbial Sensitivity Tests Monoterpenes / pharmacology* RNA, Fungal / biosynthesis RNA, Fungal / genetics RNA, Messenger / biosynthesis RNA, Messenger / genetics Signal Transduction / drug effects Tropolone / analogs & derivatives* Tropolone / pharmacology |
| IF | 1.863 |
| Times Cited | 25 |
| WOS Category | PHARMACOLOGY & PHARMACY |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | |
| Total number of mentions | 9 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| General Microbes | JCM 1542 JCM 2074 JCM 2076 |