RRC ID 15612
著者 Tago R, Yamauchi S, Maruyama M, Akiyama K, Sugahara T, Kishida T, Koba Y.
タイトル Structure-antibacterial activity relationship for 9-O,9'-O-demethyl (+)-virgatusin.
ジャーナル Biosci Biotechnol Biochem
Abstract The relationship between the antibacterial activity and structure of 9-O,9'-O-demethyl (+)-virgatusin (Virg 3) was examined. The conversion of hydroxy groups on the 9 and 9' positions to amino groups increased the activity. It was found that the 3'-methoxy group was more important for higher activity than the 4'-methoxy group on the 7'-phenyl group, and that the 3,4-methylenedioxy group on the 7-phenyl group was necessary for activity.
巻・号 72(4)
ページ 1032-7
公開日 2008-4-1
DOI 10.1271/bbb.70783
PII JST.JSTAGE/bbb/70783
PMID 18391445
MeSH Anti-Bacterial Agents / chemistry* Anti-Bacterial Agents / pharmacology* Biological Products / chemistry Biological Products / pharmacology Furans / chemistry* Furans / pharmacology* Lignans / chemistry Lignans / pharmacology Microbial Sensitivity Tests Structure-Activity Relationship
IF 1.516
引用数 6
WOS 分野 FOOD SCIENCE & TECHNOLOGY CHEMISTRY, APPLIED BIOTECHNOLOGY & APPLIED MICROBIOLOGY BIOCHEMISTRY & MOLECULAR BIOLOGY
リソース情報
一般微生物 JCM 1649 JCM 6977 JCM 11481