RRC ID 15623
著者 Ongol MP, Iguchi T, Tanaka M, Sone T, Ikeda H, Asano K, Nishimura T.
タイトル Potential of selected strains of lactic acid bacteria to induce a Th1 immune profile.
ジャーナル Biosci Biotechnol Biochem
Abstract Lactic acid bacteria (LAB) might switch the Th2 biased immune response in allergic patients towards a balanced Th1/Th2 immune profile, leading to amelioration of allergy. To select strains of LAB that could be of potential application for foods in controlling allergy, 35 bacterial strains were screened in vitro using murine splenocytes and peritoneal exudate cells (PECs). Streptococcus thermophilus AHU1838 (FERM AP-21009), and Lactobacillus paracasei subsp. casei AHU1839 (FERM AP-21010) enhanced the secretion of Th1 cytokines such as interferon-gamma (IFN-gamma) and interleukin-12 (IL-12). The two strains of LAB also up-regulated the expression of CD40, and CD86 in dendritic cells (DCs), and activated cytotoxic T lymphocytes (CTL). These two strains could therefore be used in producing fermented food products that can enhance the Th1 immune profile which is important in ameliorating allergy.
巻・号 72(11)
ページ 2847-57
公開日 2008-11-1
DOI 10.1271/bbb.80307
PII JST.JSTAGE/bbb/80307
PMID 18997432
MeSH Animals Bacteria / classification Bacteria / immunology* Bacteria / metabolism* Cattle Cell Line, Tumor Exudates and Transudates / cytology Exudates and Transudates / immunology Gene Expression Regulation Interferon-gamma / metabolism Interleukin-10 / metabolism Interleukin-12 / metabolism Lactic Acid / biosynthesis* Mice Monocytes / immunology Peritoneum / metabolism T-Lymphocytes, Cytotoxic / immunology Th1 Cells / immunology*
IF 1.516
引用数 18
WOS 分野 FOOD SCIENCE & TECHNOLOGY CHEMISTRY, APPLIED BIOTECHNOLOGY & APPLIED MICROBIOLOGY BIOCHEMISTRY & MOLECULAR BIOLOGY
リソース情報
一般微生物 JCM 1001 JCM 1002 JCM 1025 JCM 1028 JCM 1034 JCM 1173 JCM 1192 JCM 5813 JCM 5818 JCM 7017 JCM 8787 JCM 8788 JCM 8790 JCM 11039