| RRC ID |
15670
|
| 著者 |
Ibrahim el-SM, Rahman AK, Isoda R, Umeda K, Van Sa N, Kodama Y.
|
| タイトル |
In vitro and in vivo effectiveness of egg yolk antibody against Candida albicans (anti-CA IgY).
|
| ジャーナル |
Vaccine
|
| Abstract |
We prepared anti-Candida albicans antibody in chicken egg yolk (anti-CA IgY) and investigated its in vitro and in vivo effectiveness. Anti-CA IgY significantly reduced the adherence capacity of C. albicans to FaDu cells (human pharynx carcinoma cells) in a dose-dependent manner. The protective efficacy of anti-CA IgY was investigated in experimentally induced oral candidiasis in immunosuppressed mice. Oral administration of anti-CA IgY significantly reduced the number of C. albicans and the scores of the tongue lesions. Moreover, anti-CA IgY reduced the colonization of C. albicans in mice organs. These results indicate that anti-CA IgY has a protective effect against the oral candidiasis of experimentally infected mice and reduces the dissemination of C. albicans. Putting together, these results indicate that anti-CA IgY is effective against C. albicans. This effect might be due to the blocking of the binding of C. albicans to the host cells. Therefore, anti-CA IgY might be considered as a prophylactic immunotherapy or possibly an adjunctive antifungal therapy.
|
| 巻・号 |
26(17)
|
| ページ |
2073-80
|
| 公開日 |
2008-4-16
|
| DOI |
10.1016/j.vaccine.2008.02.046
|
| PII |
S0264-410X(08)00232-6
|
| PMID |
18375022
|
| MeSH |
Animals
Antibodies, Fungal / immunology
Antibodies, Fungal / pharmacology*
Candida albicans / drug effects*
Candida albicans / immunology
Candidiasis / drug therapy
Candidiasis / immunology*
Candidiasis / prevention & control
Candidiasis, Oral / microbiology
Cell Line, Tumor
Egg Yolk / immunology*
Humans
Immunoglobulins / immunology
Mice
|
| IF |
3.143
|
| 引用数 |
31
|
|
WOS 分野
|
MEDICINE, RESEARCH & EXPERIMENTAL
IMMUNOLOGY
|
| リソース情報 |
| 一般微生物 |
JCM 1542 |
