論文 - 詳細
| RRC ID | 15670 |
|---|---|
| 著者 | Ibrahim el-SM, Rahman AK, Isoda R, Umeda K, Van Sa N, Kodama Y. |
| タイトル | In vitro and in vivo effectiveness of egg yolk antibody against Candida albicans (anti-CA IgY). |
| ジャーナル | Vaccine |
| Abstract |
We prepared anti-Candida albicans antibody in chicken egg yolk (anti-CA IgY) and investigated its in vitro and in vivo effectiveness. Anti-CA IgY significantly reduced the adherence capacity of C. albicans to FaDu cells (human pharynx carcinoma cells) in a dose-dependent manner. The protective efficacy of anti-CA IgY was investigated in experimentally induced oral candidiasis in immunosuppressed mice. Oral administration of anti-CA IgY significantly reduced the number of C. albicans and the scores of the tongue lesions. Moreover, anti-CA IgY reduced the colonization of C. albicans in mice organs. These results indicate that anti-CA IgY has a protective effect against the oral candidiasis of experimentally infected mice and reduces the dissemination of C. albicans. Putting together, these results indicate that anti-CA IgY is effective against C. albicans. This effect might be due to the blocking of the binding of C. albicans to the host cells. Therefore, anti-CA IgY might be considered as a prophylactic immunotherapy or possibly an adjunctive antifungal therapy. |
| 巻・号 | 26(17) |
| ページ | 2073-80 |
| 公開日 | 2008-4-16 |
| DOI | 10.1016/j.vaccine.2008.02.046 |
| PII | S0264-410X(08)00232-6 |
| PMID | 18375022 |
| MeSH | Animals Antibodies, Fungal / immunology Antibodies, Fungal / pharmacology* Candida albicans / drug effects* Candida albicans / immunology Candidiasis / drug therapy Candidiasis / immunology* Candidiasis / prevention & control Candidiasis, Oral / microbiology Cell Line, Tumor Egg Yolk / immunology* Humans Immunoglobulins / immunology Mice |
| IF | 3.143 |
| 引用数 | 31 |
| WOS 分野 | MEDICINE, RESEARCH & EXPERIMENTAL IMMUNOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 一般微生物 | JCM 1542 |