Reference - Detail
| RRC ID | 15688 |
|---|---|
| Author | Li C, Hisamoto N, Nix P, Kanao S, Mizuno T, Bastiani M, Matsumoto K. |
| Title | The growth factor SVH-1 regulates axon regeneration in C. elegans via the JNK MAPK cascade. |
| Journal | Nat Neurosci |
| Abstract |
The ability of neurons to undergo regenerative growth after injury is governed by cell-intrinsic and cell-extrinsic regeneration pathways. These pathways represent potential targets for therapies to enhance regeneration. However, the signaling pathways that orchestrate axon regeneration are not well understood. In Caenorhabditis elegans, the Jun N-terminal kinase (JNK) and p38 MAP kinase (MAPK) pathways are important for axon regeneration. We found that the C. elegans SVH-1 growth factor and its receptor, SVH-2 tyrosine kinase, regulate axon regeneration. Loss of SVH-1-SVH-2 signaling resulted in a substantial defect in the ability of neurons to regenerate, whereas its activation improved regeneration. Furthermore, SVH-1-SVH-2 signaling was initiated extrinsically by a pair of sensory neurons and functioned upstream of the JNK-MAPK pathway. Thus, SVH-1-SVH-2 signaling via activation of the MAPK pathway acts to coordinate neuron regeneration response after axon injury. |
| Volume | 15(4) |
| Pages | 551-7 |
| Published | 2012-3-4 |
| DOI | 10.1038/nn.3052 |
| PII | nn.3052 |
| PMID | 22388962 |
| MeSH | Amino Acid Sequence Animals Animals, Genetically Modified Axons / enzymology Axons / physiology* Caenorhabditis elegans Caenorhabditis elegans Proteins / physiology* Intercellular Signaling Peptides and Proteins / physiology* JNK Mitogen-Activated Protein Kinases / physiology MAP Kinase Signaling System / physiology* Molecular Sequence Data Nerve Regeneration / physiology* |
| IF | 20.071 |
| Times Cited | 42 |
| WOS Category | NEUROSCIENCES |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 7 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| C.elegans | tm737 tm2646 |