| RRC ID |
15720
|
| Author |
Orikasa Y, Ichinohe K, Saito J, Hashimoto S, Matsumoto K, Ooi T, Taguchi S.
|
| Title |
The hydrophobicity in a chemically modified side-chain of cysteine residues of thanatin is related to antimicrobial activity against Micrococcus luteus.
|
| Journal |
Biosci Biotechnol Biochem
|
| Abstract |
The chemically modified thanatins with the methyl group (CH(3)), ethyl group (C(2)H(5)), and normal-octyl group (C(8)H(17)) at the side-chain of cysteine residues were synthesized. The octyl group modified form exhibited 8-fold higher antimicrobial activity against Micrococcus luteus than wild type thanatin. It was found that there was an equilateral correlation between antimicrobial activity and side-chain hydrophobicity at the cysteine residues in thanatin.
|
| Volume |
73(7)
|
| Pages |
1683-4
|
| Published |
2009-7-1
|
| DOI |
10.1271/bbb.90183
|
| PII |
JST.JSTAGE/bbb/90183
|
| PMID |
19584529
|
| MeSH |
Amino Acid Sequence
Anti-Infective Agents / chemical synthesis
Anti-Infective Agents / chemistry*
Anti-Infective Agents / pharmacology*
Antimicrobial Cationic Peptides
Cysteine / chemistry*
Hydrophobic and Hydrophilic Interactions*
Microbial Sensitivity Tests
Micrococcus luteus / drug effects*
Molecular Sequence Data
Peptides, Cyclic / chemical synthesis
Peptides, Cyclic / chemistry*
Peptides, Cyclic / pharmacology*
Structure-Activity Relationship
|
| IF |
1.516
|
| Times Cited |
6
|
|
WOS Category
|
FOOD SCIENCE & TECHNOLOGY
CHEMISTRY, APPLIED
BIOTECHNOLOGY & APPLIED MICROBIOLOGY
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
| Resource |
| General Microbes |
JCM 3347 |
