Reference - Detail
| RRC ID | 15827 |
|---|---|
| Author | Sawai H, Na K, Sasaki N, Mimitsuka T, Minegishi S, Henmi M, Yamada K, Shimizu S, Yonehara T. |
| Title | Membrane-integrated fermentation system for improving the optical purity of D-lactic acid produced during continuous fermentation. |
| Journal | Biosci Biotechnol Biochem |
| Abstract |
This report describes the production of highly optically pure D-lactic acid by the continuous fermentation of Sporolactobacillus laevolacticus and S. inulinus, using a membrane-integrated fermentation (MFR) system. The optical purity of D-lactic acid produced by the continuous fermentation system was greater than that produced by batch fermentation; the maximum value for the optical purity of D-lactic acid reached 99.8% enantiomeric excess by continuous fermentation when S. leavolacticus was used. The volumetric productivity of the optically pure D-lactic acid was about 12 g/L/h, this being approximately 11-fold higher than that obtained by batch fermentation. An enzymatic analysis indicated that both S. laevolacticus and S. inulinus could convert L-lactic acid to D-lactic acid by isomerization after the late-log phase. These results provide evidence for an effective bio-process to produce D-lactic acid of greater optical purity than has conventionally been achieved to date. |
| Volume | 75(12) |
| Pages | 2326-32 |
| Published | 2011-1-1 |
| DOI | 10.1271/bbb.110486 |
| PII | JST.JSTAGE/bbb/110486 |
| PMID | 22146719 |
| MeSH | Bacillales / cytology* Bacillales / enzymology Bacillales / metabolism* Bioreactors / microbiology* Cell Membrane / metabolism* Fermentation* L-Lactate Dehydrogenase / metabolism Lactic Acid / biosynthesis* Lactic Acid / chemistry Lactobacillus / metabolism Optical Phenomena* Stereoisomerism |
| IF | 1.516 |
| Times Cited | 11 |
| WOS Category | FOOD SCIENCE & TECHNOLOGY BIOTECHNOLOGY & APPLIED MICROBIOLOGY CHEMISTRY, APPLIED BIOCHEMISTRY & MOLECULAR BIOLOGY |
| Altmetric score |
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| The most frequently cited source | Patent(IFI CLAIMS) |
| Total number of mentions | 4 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| General Microbes | JCM 1012 JCM 1164 JCM 2513 JCM 2515 JCM 6014 JCM 6124 |