論文 - 詳細
| RRC ID | 16046 |
|---|---|
| 著者 | Kawaoka S, Kadota K, Arai Y, Suzuki Y, Fujii T, Abe H, Yasukochi Y, Mita K, Sugano S, Shimizu K, Tomari Y, Shimada T, Katsuma S. |
| タイトル | The silkworm W chromosome is a source of female-enriched piRNAs. |
| ジャーナル | RNA |
| Abstract |
In the silkworm, Bombyx mori, the W chromosome plays a dominant role in female determination. However, neither protein-coding genes nor transcripts have so far been isolated from the W chromosome. Instead, a large amount of functional transposable elements and their remnants are accumulated on the W chromosome. PIWI-interacting RNAs (piRNAs) are 23-30-nt-long small RNAs that potentially act as sequence-specific guides for PIWI proteins to silence transposon activity in animal gonads. In this study, by comparing ovary- and testis-derived piRNAs, we identified numerous female-enriched piRNAs. Our data indicated that female-enriched piRNAs are derived from the W chromosome. Moreover, comparative analyses on piRNA profiles from a series of W chromosome mutant strains revealed a striking enrichment of a specific set of transposon-derived piRNAs in the putative sex-determining region. Collectively, we revealed the nature of the silkworm W chromosome as a source of piRNAs. |
| 巻・号 | 17(12) |
| ページ | 2144-51 |
| 公開日 | 2011-12-1 |
| DOI | 10.1261/rna.027565.111 |
| PII | rna.027565.111 |
| PMID | 22020973 |
| PMC | PMC3222127 |
| MeSH | Animals Bombyx / genetics* Bombyx / metabolism Chromosomes, Insect / genetics* DNA Transposable Elements Female Gene Expression Regulation Gonads / metabolism Male Models, Genetic RNA, Small Interfering / genetics* RNA, Small Interfering / metabolism Sex Characteristics Sex Chromosomes / genetics* Sex Determination Processes |
| IF | 4.32 |
| 引用数 | 29 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY |
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