| RRC ID |
1629
|
| 著者 |
Kawabata T, Fukuchi S, Homma K, Ota M, Araki J, Ito T, Ichiyoshi N, Nishikawa K.
|
| タイトル |
GTOP: a database of protein structures predicted from genome sequences.
|
| ジャーナル |
Nucleic Acids Res
|
| Abstract |
Large-scale genome projects generate an unprecedented number of protein sequences, most of them are experimentally uncharacterized. Predicting the 3D structures of sequences provides important clues as to their functions. We constructed the Genomes TO Protein structures and functions (GTOP) database, containing protein fold predictions of a huge number of sequences. Predictions are mainly carried out with the homology search program PSI-BLAST, currently the most popular among high-sensitivity profile search methods. GTOP also includes the results of other analyses, e.g. homology and motif search, detection of transmembrane helices and repetitive sequences. We have completed analyzing the sequences of 41 organisms, with the number of proteins exceeding 120 000 in total. GTOP uses a graphical viewer to present the analytical results of each ORF in one page in a 'color-bar' format. The assigned 3D structures are presented by Chime plug-in or RasMol. The binding sites of ligands are also included, providing functional information. The GTOP server is available at http://spock.genes.nig.ac.jp/~genome/gtop.html.
|
| 巻・号 |
30(1)
|
| ページ |
294-8
|
| 公開日 |
2002-1-1
|
| DOI |
10.1093/nar/30.1.294
|
| PMID |
11752318
|
| PMC |
PMC99104
|
| MeSH |
Amino Acid Motifs
Animals
Databases, Protein*
Forecasting
Genome*
Humans
Imaging, Three-Dimensional
Information Storage and Retrieval
Internet
Open Reading Frames
Protein Folding
Protein Structure, Tertiary
Proteins / chemistry*
Proteins / genetics*
Proteins / physiology
Repetitive Sequences, Amino Acid
Sequence Alignment
Sequence Homology, Amino Acid
Structure-Activity Relationship
|
| IF |
11.502
|
| 引用数 |
61
|
|
WOS 分野
|
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
| リソース情報 |
| 情報 |
E.coli |
