論文 - 詳細
| RRC ID | 17465 |
|---|---|
| 著者 | Kawahara T. |
| タイトル | Inhibitory effect of heat-killed Lactobacillus strain on immunoglobulin E-mediated degranulation and late-phase immune reactions of mouse bone marrow-derived mast cells. |
| ジャーナル | Anim Sci J |
| Abstract |
This study investigated the in vitro effect of Lactobacillus strains, a major group of probiotic lactic acid bacteria, on immunoglobulin E (IgE)- and antigen-induced mast cell degranulation and subsequent gene expression. Bone marrow-derived mast cells (BMMCs) from DBA/2 mice were cultured with heat-killed Lactobacillus strains for 24 h. Some strains significantly inhibited IgE- and antigen-induced β-hexosaminidase release from BMMCs. Furthermore, Lactobacillus reuteri NBRC 15892, which exhibited the strongest inhibitory activity, significantly reduced the elevated interleukin (IL)-4, IL-13, tumor necrosis factor-α, and cyclooxygenase-2 expression levels that was induced by 1-2 h of stimulation with IgE and antigens. The suppressive effect of NBRC 15892 strain on BMMC degranulation was significantly reduced in the presence of a toll-like receptor (TLR)2-neutralizing antibody. In addition, downregulation of cell surface FcεRIα expression was observed after 6 h of NBRC 15892 treatment. These results suggest that some Lactobacillus strains inhibited IgE-mediated mast cell degranulation and subsequent late-phase reactions involving mast cells via a TLR2-dependent mechanism with FcεRIα downregulation. |
| 巻・号 | 81(6) |
| ページ | 714-21 |
| 公開日 | 2010-12-1 |
| DOI | 10.1111/j.1740-0929.2010.00788.x |
| PMID | 21108693 |
| MeSH | Animals Bone Marrow Cells / immunology* Bone Marrow Cells / metabolism Cell Degranulation* Cyclooxygenase 2 / metabolism Down-Regulation Immunoglobulin E / immunology* Interleukin-13 / metabolism Interleukin-4 / metabolism Lactobacillus* Male Mast Cells / immunology* Mast Cells / metabolism Mice Mice, Inbred DBA Probiotics / pharmacology* Receptors, IgE / immunology Toll-Like Receptor 2 / immunology Tumor Necrosis Factor-alpha / metabolism beta-N-Acetylhexosaminidases / metabolism |
| IF | 1.399 |
| 引用数 | 15 |
| WOS 分野 | AGRICULTURE, DAIRY & ANIMAL SCIENCE |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 一般微生物 | JCM 1002 JCM 1028 JCM 1096 JCM 1132 JCM 1185 JCM 1248 JCM 2009 JCM 2012 JCM 2122 JCM 20398 |