RRC ID 17501
著者 Kawamoto S, Tran TH, Maruya M, Suzuki K, Doi Y, Tsutsui Y, Kato LM, Fagarasan S.
タイトル The inhibitory receptor PD-1 regulates IgA selection and bacterial composition in the gut.
ジャーナル Science
Abstract Immunoglobulin A (IgA) is essential to maintain the symbiotic balance between gut bacterial communities and the host immune system. Here we provide evidence that the inhibitory co-receptor programmed cell death-1 (PD-1) regulates the gut microbiota through appropriate selection of IgA plasma cell repertoires. PD-1 deficiency generates an excess number of T follicular helper (T(FH)) cells with altered phenotypes, which results in dysregulated selection of IgA precursor cells in the germinal center of Peyer's patches. Consequently, the IgAs produced in PD-1-deficient mice have reduced bacteria-binding capacity, which causes alterations of microbial communities in the gut. Thus, PD-1 plays a critical role in regulation of antibody diversification required for the maintenance of intact mucosal barrier.
巻・号 336(6080)
ページ 485-9
公開日 2012-4-27
DOI 10.1126/science.1217718
PII 336/6080/485
PMID 22539724
MeSH Adoptive Transfer Animals B-Lymphocytes / immunology* Bacteria / immunology Bacterial Load Bacterial Physiological Phenomena* Feces / microbiology Genes, Immunoglobulin Heavy Chain Germinal Center / cytology Germinal Center / immunology Immunoglobulin A / biosynthesis Immunoglobulin A / immunology* Intestinal Mucosa / immunology* Intestine, Small / immunology Intestine, Small / microbiology* Lymphocyte Count Mice Peyer's Patches / cytology Peyer's Patches / immunology Plasma Cells / immunology Plasma Cells / physiology Programmed Cell Death 1 Receptor / genetics Programmed Cell Death 1 Receptor / physiology* Symbiosis T-Lymphocytes, Helper-Inducer / immunology*
IF 41.846
引用数 230
WOS 分野 IMMUNOLOGY
リソース情報
実験動物マウス RBRC02142