RRC ID 17511
著者 Kamo H, Honda K, Kitagawa J, Tsuboi Y, Kondo M, Taira M, Yamashita A, Katsuyama N, Masuda Y, Kato T, Iwata K.
タイトル Topical capsaicin application causes cold hypersensitivity in awake monkeys.
ジャーナル J Oral Sci
Abstract Recent animal studies have demonstrated that many trigeminal ganglion neurons co-express TRPV1 and TRPA1 receptors following peripheral inflammation. In the present study, we examined whether cold receptors were sensitized by capsaicin in awake monkeys. Two monkeys were trained to detect a change in cold stimulus temperature (30 degrees C to 0.5, 1.0, 1.5 or 2.0 degrees C) applied to the facial skin. A total of 589 trials were studied, and the number of escape and hold-through trials and detection latency were measured. The number of escape trials was increased after capsaicin treatment, whereas that of hold-through trials was decreased. Detection latency was significantly decreased after capsaicin treatment. The present findings suggest that topical application of capsaicin to the facial skin induces reversible hypersensitivity to a facial cold stimulus in behaving monkeys.
巻・号 50(2)
ページ 175-9
公開日 2008-6-1
DOI 10.2334/josnusd.50.175
PII JST.JSTAGE/josnusd/50.175
PMID 18587207
MeSH Administration, Cutaneous Animals Capsaicin / administration & dosage Capsaicin / pharmacology* Cold Temperature* Face / innervation Macaca Reaction Time / drug effects Sensory System Agents / administration & dosage Sensory System Agents / pharmacology* Sensory Thresholds / drug effects* Skin / drug effects Skin / innervation TRPV Cation Channels / drug effects Thermoreceptors / drug effects* Wakefulness
IF 1.2
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