Reference - Detail
| RRC ID | 17535 |
|---|---|
| Author | Boneva NB, Mori Y, Kaplamadzhiev DB, Kikuchi H, Zhu H, Kikuchi M, Tonchev AB, Yamashima T. |
| Title | Differential expression of FABP 3, 5, 7 in infantile and adult monkey cerebellum. |
| Journal | Neurosci Res |
| Abstract |
To clarify the involvement of fatty acid binding proteins (FABPs) in cerebellar development and function, we explored the distribution of three brain-expressed FABPs, FABP 3, 5 and 7, by comparing three animal groups--infantile, normal and postischemic adult monkeys. Immunoblotting analysis revealed intense expression of FABP 3 and 7, but not of FABP5, in the control and postischemic adult cerebellum. The protein levels of FABP7, but not of FABP 3 or 5, gradually increased until 2 weeks after the insult. Immunohistochemical analysis showed that cerebellar FABP3-positive cells were Purkinje cells and Bergmann glia. FABP5-positive cells were found only in the postischemic cerebellum, and were identified as activated microglia. Interestingly, in the infantile cerebellum, both the granule cell progenitors in the external granular layer (EGL) and the oligodendrocyte progenitors in the internal granular layer (IGL) expressed FABP5. In the adult cerebellum, FABP7 was expressed in Purkinje cells and basket interneurons, while in the infantile cerebellum it was also found in Bergmann glia. These results showed differential expression of FABPs in cerebellar neuronal and glial cell types; FABP 3 and 7 were predominantly expressed in normal cerebellum, FABP5 after ischemic injury, while FABP 3, 5 and 7 were expressed during cerebellar development. |
| Volume | 68(2) |
| Pages | 94-102 |
| Published | 2010-10-1 |
| DOI | 10.1016/j.neures.2010.07.2028 |
| PII | S0168-0102(10)02199-1 |
| PMID | 20620177 |
| MeSH | Age Factors Analysis of Variance Animals Animals, Newborn Bromodeoxyuridine / metabolism Cerebellum / cytology Cerebellum / growth & development* Cerebellum / metabolism* Fatty Acid-Binding Proteins / classification Fatty Acid-Binding Proteins / metabolism* Fluoresceins Gene Expression Regulation, Developmental / physiology* Ischemia / metabolism Ischemia / pathology Macaca fascicularis Neuroglia / metabolism Neurons / metabolism Organic Chemicals / metabolism |
| IF | 2.645 |
| Times Cited | 13 |
| WOS Category | NEUROSCIENCES |
| Altmetric score |
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| The most frequently cited source | Patent(IFI CLAIMS) |
| Total number of mentions | 1 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Japanese macaques | |