RRC ID 17541
Author Andreau JM, Funahashi S.
Title Primate prefrontal neurons encode the association of paired visual stimuli during the pair-association task.
Journal Brain Cogn
Abstract The prefrontal cortex (PFC) is known to contribute to memory processes such as encoding representations into long-term-memory (LTM) and retrieving these representations from LTM. However, the details of the PFC's contribution to LTM processes are not well known. To examine the characteristics of the PFC's contribution to LTM processes, we analyzed single-neuron activity while monkeys performed a pair-association (PA) task using 12 pairs of complex visual images. Among 60 neurons with sample-period activity, 32% showed the strongest and second-strongest sample-period activities when a particular pair of stimuli was presented (pair selectivity). In addition, the mean latency of sample-period activity was 138 ms in the PFC, which was longer than that observed in ITC neurons under bottom-up conditions, but shorter than that under top-down conditions. These results indicate that the PFC participates in encoding and retrieving information in LTM processes and that pair-selective sample-period activity might be a candidate for the top-down signal that the PFC provides to the ITC during the retrieval of information from LTM.
Volume 76(1)
Pages 58-69
Published 2011-6-1
DOI 10.1016/j.bandc.2011.03.001
PII S0278-2626(11)00047-9
PMID 21450383
MeSH Analysis of Variance Animals Association Learning / physiology* Electrophysiology Macaca Male Memory / physiology Neurons / physiology* Photic Stimulation Prefrontal Cortex / physiology* Reaction Time / physiology Visual Perception / physiology*
IF 2.508
Times Cited 2
Japanese macaques