Reference - Detail
| RRC ID | 17684 |
|---|---|
| Author | Yamauchi Y, Izumi Y, Asakura K, Fukutomi T, Serizawa A, Kawai K, Wakui M, Suematsu M, Nomori H. |
| Title | Lovastatin and valproic acid additively attenuate cell invasion in ACC-MESO-1 cells. |
| Journal | Biochem Biophys Res Commun |
| Abstract |
Malignant pleural mesothelioma is known to be widely resistant to therapy and new treatment strategies are needed. Both statins and valproic acid are known to suppress the growth of multiple cancer lines, but the effects on mesothelioma cells are not well defined. In the present study we examined the effects of lovastatin and valproic acid on ACC-MESO-1, which is a human derived mesothelioma cell line. We found that lovastatin (2 μM) and/or valproic acid (5 mM) did not reduce cell viability nor induce apoptosis, but reduced cell invasion. The effect was additive when combined. Furthermore it was speculated that induction of autophagic changes was at least in part involved in this process. |
| Volume | 410(2) |
| Pages | 328-32 |
| Published | 2011-7-1 |
| DOI | 10.1016/j.bbrc.2011.05.149 |
| PII | S0006-291X(11)00933-8 |
| PMID | 21672521 |
| MeSH | Antineoplastic Combined Chemotherapy Protocols* Autophagy Cell Line, Tumor Drug Synergism Humans Lovastatin / administration & dosage* Mesothelioma / drug therapy* Mesothelioma / pathology Neoplasm Invasiveness Solitary Fibrous Tumor, Pleural / drug therapy* Solitary Fibrous Tumor, Pleural / pathology Valproic Acid / administration & dosage* |
| IF | 2.985 |
| Times Cited | 8 |
| WOS Category | BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY |
| Altmetric score |
オルトメトリクス指標項目
|
| Total number of mentions | 0 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | ACC-MESO-1(RCB2292) |