| RRC ID |
17684
|
| Author |
Yamauchi Y, Izumi Y, Asakura K, Fukutomi T, Serizawa A, Kawai K, Wakui M, Suematsu M, Nomori H.
|
| Title |
Lovastatin and valproic acid additively attenuate cell invasion in ACC-MESO-1 cells.
|
| Journal |
Biochem Biophys Res Commun
|
| Abstract |
Malignant pleural mesothelioma is known to be widely resistant to therapy and new treatment strategies are needed. Both statins and valproic acid are known to suppress the growth of multiple cancer lines, but the effects on mesothelioma cells are not well defined. In the present study we examined the effects of lovastatin and valproic acid on ACC-MESO-1, which is a human derived mesothelioma cell line. We found that lovastatin (2 μM) and/or valproic acid (5 mM) did not reduce cell viability nor induce apoptosis, but reduced cell invasion. The effect was additive when combined. Furthermore it was speculated that induction of autophagic changes was at least in part involved in this process.
|
| Volume |
410(2)
|
| Pages |
328-32
|
| Published |
2011-7-1
|
| DOI |
10.1016/j.bbrc.2011.05.149
|
| PII |
S0006-291X(11)00933-8
|
| PMID |
21672521
|
| MeSH |
Antineoplastic Combined Chemotherapy Protocols*
Autophagy
Cell Line, Tumor
Drug Synergism
Humans
Lovastatin / administration & dosage*
Mesothelioma / drug therapy*
Mesothelioma / pathology
Neoplasm Invasiveness
Solitary Fibrous Tumor, Pleural / drug therapy*
Solitary Fibrous Tumor, Pleural / pathology
Valproic Acid / administration & dosage*
|
| IF |
2.985
|
| Times Cited |
8
|
|
WOS Category
|
BIOPHYSICS
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
| Resource |
| Human and Animal Cells |
ACC-MESO-1(RCB2292) |
