Reference - Detail
RRC ID | 1792 |
---|---|
Author | Kusama S, Ueda R, Suda T, Nishihara S, Matsuura ET. |
Title | Involvement of Drosophila Sir2-like genes in the regulation of life span. |
Journal | Genes Genet Syst |
Abstract |
In Drosophila melanogaster, the Sir2 gene and four Sir2-like genes have been found to be homologous to yeast SIR2 genes. To examine whether the fly Sir2, CG5216, and two Sir2-like genes, CG5085 and CG6284, affect life span, we suppressed their expression using RNAi. Decreased expression of the Sir2 and Sir2-like genes in all cells caused lethality during development. Suppression of the Sir2 in neurons and ubiquitous silencing of the Sir2-like genes shortened life spans. The effects were severer at 28 degrees C than at 25 degrees C. These results suggest that Sir2-like genes as well as Sir2 are involved in the regulation of life span in Drosophila. |
Volume | 81(5) |
Pages | 341-8 |
Published | 2006-10-1 |
DOI | 10.1266/ggs.81.341 |
PII | JST.JSTAGE/ggs/81.341 |
PMID | 17159295 |
MeSH | Animals Drosophila Proteins / genetics* Drosophila melanogaster / genetics* Drosophila melanogaster / physiology Histone Deacetylases / genetics* Longevity / genetics* Sirtuins / genetics* |
IF | 0.917 |
Times Cited | 18 |
WOS Category | GENETICS & HEREDITY BIOCHEMISTRY & MOLECULAR BIOLOGY |
Resource | |
Drosophila | 5216R-1 5216R-2 6824R-1 6824R-2 5085R-3 5085R-5 6284R-2 6284R-4 |