Reference - Detail
| RRC ID | 1792 |
|---|---|
| Author | Kusama S, Ueda R, Suda T, Nishihara S, Matsuura ET. |
| Title | Involvement of Drosophila Sir2-like genes in the regulation of life span. |
| Journal | Genes Genet Syst |
| Abstract |
In Drosophila melanogaster, the Sir2 gene and four Sir2-like genes have been found to be homologous to yeast SIR2 genes. To examine whether the fly Sir2, CG5216, and two Sir2-like genes, CG5085 and CG6284, affect life span, we suppressed their expression using RNAi. Decreased expression of the Sir2 and Sir2-like genes in all cells caused lethality during development. Suppression of the Sir2 in neurons and ubiquitous silencing of the Sir2-like genes shortened life spans. The effects were severer at 28 degrees C than at 25 degrees C. These results suggest that Sir2-like genes as well as Sir2 are involved in the regulation of life span in Drosophila. |
| Volume | 81(5) |
| Pages | 341-8 |
| Published | 2006-10-1 |
| DOI | 10.1266/ggs.81.341 |
| PII | JST.JSTAGE/ggs/81.341 |
| PMID | 17159295 |
| MeSH | Animals Drosophila Proteins / genetics* Drosophila melanogaster / genetics* Drosophila melanogaster / physiology Histone Deacetylases / genetics* Longevity / genetics* Sirtuins / genetics* |
| IF | 0.917 |
| Times Cited | 18 |
| WOS Category | GENETICS & HEREDITY BIOCHEMISTRY & MOLECULAR BIOLOGY |
| Resource | |
| Drosophila | 6284R-4 5216R-1 5216R-2 6824R-1 6824R-2 5085R-3 5085R-5 6284R-2 |