論文 - 詳細
RRC ID | 1794 |
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著者 | Tajiri R, Tsuji T, Ueda R, Saigo K, Kojima T. |
タイトル | Fate determination of Drosophila leg distal regions by trachealess and tango through repression and stimulation, respectively, of Bar homeobox gene expression in the future pretarsus and tarsus. |
ジャーナル | Dev Biol |
Abstract |
During tissue patterning, developing fields may be subdivided into several non-overlapping domains by region-specific expression of transcription factors. In Drosophila leg development, the most distal segments, the pretarsus and tarsal segment 5 (ta5), are precisely specified by interactions between tarsus homeobox genes (BarH1 and BarH2) and pretarsus homeobox genes (aristaless, clawless, and Lim1). Here, we demonstrate that trachealess and tango, both encoding bHLH-PAS proteins that are required for the formation of the embryonic tracheal system, are essential for forming two adjacent distal segments of the leg. trachealess is expressed in the pretarsus and ta5, and the concerted action of trachealess and tango seems to modulate the activity of homeobox gene regulatory loops by repressing Bar in the pretarsus and activating Bar in ta5. |
巻・号 | 303(2) |
ページ | 461-73 |
公開日 | 2007-3-15 |
DOI | 10.1016/j.ydbio.2006.11.026 |
PII | S0012-1606(06)01383-2 |
PMID | 17187773 |
MeSH | Animals Aryl Hydrocarbon Receptor Nuclear Translocator / genetics* Aryl Hydrocarbon Receptor Nuclear Translocator / metabolism Base Sequence Body Patterning / genetics Cadherins / metabolism DNA Primers / genetics Drosophila / genetics* Drosophila / growth & development* Drosophila / metabolism Drosophila Proteins / genetics* Drosophila Proteins / metabolism Enhancer Elements, Genetic Extremities / growth & development Eye Proteins / genetics Gene Expression Regulation, Developmental Genes, Homeobox* Genes, Insect* Homeodomain Proteins Models, Biological Transcription Factors / genetics* Transcription Factors / metabolism |
IF | 2.896 |
引用数 | 10 |
WOS 分野 | DEVELOPMENTAL BIOLOGY |
リソース情報 | |
ショウジョウバエ | 11987R-1 11987R-3 6883R-1 6883R-2 |