論文 - 詳細
| RRC ID | 18091 |
|---|---|
| 著者 | Thompson H, Ohazama A, Sharpe PT, Tucker AS. |
| タイトル | The origin of the stapes and relationship to the otic capsule and oval window. |
| ジャーナル | Dev Dyn |
| Abstract |
BACKGROUND:The stapes, an ossicle found within the middle ear, is involved in transmitting sound waves to the inner ear by means of the oval window. There are several developmental problems associated with this ossicle and the oval window, which cause hearing loss. The developmental origin of these tissues has not been fully elucidated. RESULTS:Using transgenic reporter mice, we have shown that the stapes is of dual origin with the stapedial footplate being composed of cells of both neural crest and mesodermal origin. Wnt1cre/Dicer mice fail to develop neural crest-derived cartilages, therefore, have no middle ear ossicles. We have shown in these mice the mesodermal stapedial footplate fails to form and the oval window is induced but underdeveloped. CONCLUSIONS:If the neural crest part of the stapes fails to form the mesodermal part does not develop, indicating that the two parts are interdependent. The stapes develops tightly associated with the otic capsule, however, it is not essential for the positioning of the oval window, suggesting that other tissues, perhaps within the inner ear are needed for oval window placement. |
| 巻・号 | 241(9) |
| ページ | 1396-404 |
| 公開日 | 2012-9-1 |
| DOI | 10.1002/dvdy.23831 |
| PMID | 22778034 |
| MeSH | Animals DEAD-box RNA Helicases / genetics DEAD-box RNA Helicases / metabolism Ear / anatomy & histology Ear / embryology* Ear / physiology Ear Ossicles / embryology Ear Ossicles / metabolism Embryo, Mammalian Female Male Mice Mice, Transgenic Models, Biological Neural Crest / embryology Neural Crest / metabolism Oval Window, Ear / cytology Oval Window, Ear / embryology* Oval Window, Ear / metabolism Pregnancy Ribonuclease III / genetics Ribonuclease III / metabolism Stapes / anatomy & histology Stapes / cytology Stapes / embryology* Stapes / metabolism Wnt1 Protein / genetics Wnt1 Protein / metabolism |
| IF | 3.275 |
| 引用数 | 29 |
| WOS 分野 | ANATOMY & MORPHOLOGY DEVELOPMENTAL BIOLOGY |
| リソース情報 | |
| 実験動物マウス | RBRC01145 |