論文 - 詳細
| RRC ID | 18188 |
|---|---|
| 著者 | Kataoka Y, Tamaki Y, Miyazaki T. |
| タイトル | Synergistic responses of superficial chemistry and micro topography of titanium created by wire-type electric discharge machining. |
| ジャーナル | Biomed Mater Eng |
| Abstract |
Wire-type electric discharge machining has been applied to the manufacture of endosseous titanium implants as this computer associated technique allows extremely accurate complex sample shaping with an optimal micro textured surface during the processing. Since the titanium oxide layer is sensitively altered by each processing, the authors hypothesized that this technique also up-regulates biological responses through the synergistic effects of the superficial chemistry and micro topography. To evaluate the respective in vitro cellular responses on the superficial chemistry and micro topography of titanium surface processed by wire-type electric discharge, we used titanium-coated epoxy resin replica of the surface. An oxide layer on the titanium surface processed by wire-type electric discharge activated the initial responses of osteoblastic cells through an integrin-mediated mechanism. Since the mRNA expression of ALP on those replicas was up-regulated compared to smooth titanium samples, the micro topography of a titanium surface processed by wire-type electric discharge promotes the osteogenic potential of cells. The synergistic response of the superficial chemistry and micro topography of titanium processed by wire-type electric discharge was demonstrated in this study. |
| 巻・号 | 21(2) |
| ページ | 113-21 |
| 公開日 | 2011-1-1 |
| DOI | 10.3233/BME-2011-0661 |
| PII | B66NW21074MV3552 |
| PMID | 21654067 |
| MeSH | Alkaline Phosphatase / metabolism* Animals Biocompatible Materials / chemistry* Cell Adhesion Cell Line Drug Synergism Epoxy Resins / chemistry Materials Testing Mice Microscopy, Electron, Scanning / methods Nanostructures / chemistry* Nanostructures / ultrastructure* Osteoblasts / enzymology* Osteoblasts / ultrastructure Surface Properties Titanium / chemistry* Up-Regulation |
| IF | 1.243 |
| 引用数 | 5 |
| WOS 分野 | ENGINEERING, BIOMEDICAL MATERIALS SCIENCE, BIOMATERIALS |
| リソース情報 | |
| ヒト・動物細胞 | MC3T3-E1(RCB1126) |