| RRC ID |
18502
|
| 著者 |
Yonezawa T, Lee JW, Akazawa H, Inagaki M, Cha BY, Nagai K, Yagasaki K, Akihisa T, Woo JT.
|
| タイトル |
Osteogenic activity of diphenyl ether-type cyclic diarylheptanoids derived from Acer nikoense.
|
| ジャーナル |
Bioorg Med Chem Lett
|
| Abstract |
Osteogenic activity of six diarylheptanoids, acerogenin A (1), (R)-acerogenin B (2), aceroside I (3), aceroside B(1) (4), aceroside III (5) and (-)-centrolobol (6) and two phenolic compounds; (+)-rhododendrol (7) and (+)-cathechin (8), isolated from the stem bark of Acer nikoense (Nikko maple) was evaluated using alkaline phosphatase (ALP) activity as a marker for early osteoblast differentiation. We found that the diphenyl ether-type cyclic diarylheptanoids 1-5 promoted ALP activity in mouse preosteoblastic MC3T3-E1 cells without affecting cell proliferation, but linear-type diarylheptanoid 6 and phenolic compounds 7 and 8 did not. Diphenyl ether-type cyclic diarylheptanoids 1-4 also increased protein production of osteocalcin, a late stage maker for osteoblast differentiation, and induced osteoblastic mineralization. Structure-activity relationships of these compounds demonstrated that the stimulative efficacy of aglycones was higher than that of its glycosides. Taken together, diphenyl ether-type cyclic diarylheptanoids promote early- and late-stage osteoblastogenesis, which may open the possibility for the development of novel osteogenic agents.
|
| 巻・号 |
21(11)
|
| ページ |
3248-51
|
| 公開日 |
2011-6-1
|
| DOI |
10.1016/j.bmcl.2011.04.041
|
| PII |
S0960-894X(11)00498-7
|
| PMID |
21550801
|
| MeSH |
Acer / chemistry*
Alkaline Phosphatase / analysis*
Animals
Biomarkers / analysis
Cell Differentiation / drug effects
Cells, Cultured
Diarylheptanoids* / chemistry
Diarylheptanoids* / pharmacology
Mice
Molecular Structure
Osteoblasts / drug effects*
Phenyl Ethers / chemistry
Phenyl Ethers / pharmacology
Plant Bark / chemistry*
Plant Extracts / chemistry*
Plant Extracts / pharmacology*
|
| IF |
2.572
|
| 引用数 |
13
|
|
WOS 分野
|
CHEMISTRY, MEDICINAL
CHEMISTRY, ORGANIC
|
| リソース情報 |
| ヒト・動物細胞 |
MC3T3-E1(RCB1126) |
