RRC ID 18538
Author Obiang P, Macrez R, Jullienne A, Bertrand T, Lesept F, Ali C, Maubert E, Vivien D, Agin V.
Title GluN2D subunit-containing NMDA receptors control tissue plasminogen activator-mediated spatial memory.
Journal J Neurosci
Abstract Tissue plasminogen activator (tPA) is a serine protease with pleiotropic actions in the CNS, such as synaptic plasticity and neuronal death. Some effects of tPA require its interaction with the GluN1 subunit of the NMDA receptor (NMDAR), leading to a potentiation of NMDAR signaling. We have reported previously that the pro-neurotoxic effect of tPA is mediated through GluN2D subunit-containing NMDARs. Thus, the aim of the present study was to determine whether GluN2D subunit-containing NMDARs drive tPA-mediated cognitive functions. To address this issue, a strategy of immunization designed to prevent the in vivo interaction of tPA with NMDARs and GluN2D-deficient mice were used in a set of behavioral tasks. Altogether, our data provide the first evidence that tPA influences spatial memory through its preferential interaction with GluN2D subunit-containing NMDARs.
Volume 32(37)
Pages 12726-34
Published 2012-9-12
DOI 10.1523/JNEUROSCI.6202-11.2012
PII 32/37/12726
PMID 22972996
PMC PMC6703808
MeSH Animals Glutamic Acid / metabolism* Male Maze Learning / physiology* Memory, Short-Term / physiology* Mice Mice, Knockout Mice, Transgenic Protein Subunits Receptors, N-Methyl-D-Aspartate / metabolism* Space Perception / physiology* Tissue Plasminogen Activator / metabolism*
IF 5.674
Times Cited 17
Mice RBRC01840