論文 - 詳細
| RRC ID | 18542 |
|---|---|
| 著者 | Chen J, Qin S, Xiao J, Tanigawa S, Uto T, Hashimoto F, Fujii M, Hou DX. |
| タイトル | A genome-wide microarray highlights the antiinflammatory genes targeted by oolong tea theasinensin A in macrophages. |
| ジャーナル | Nutr Cancer |
| Abstract |
Theasinensin A is one of the oolong tea theasinensins, which differ from green tea catechins and black tea theaflavins. In a previous study, we found that theasinesin A had a potential effect on antiinflammation since theasinensin A suppressed LPS-induced COX2 and PGE(2) production. To clarify the molecular mechanisms, we investigated the gene expression profiling in macrophage-like cells treated with theasinensin A through a genome-wide DNA microarray in the present study. Among 22,050 oligonucleotides, the expression levels of 406 genes were increased by ≥3-fold in LPS-activated RAW264 cells, 259 gene signals of which were attenuated by theasinensin A treatment (≥2-fold). Expression levels of 717 genes were decreased by ≥3-fold in LPS-activated cells, of which 471 gene signals were restored by theasinensin A treatment (≥2-fold). These genes were further categorized as "defense, inflammatory response, cytokines activities, and receptor activities," and some of them were confirmed by real-time polymerase chain reaction. Furthermore, pathways analysis revealed that theasinensin A regulated the relevant expression networks of chemokines, interleukins, and interferons to exert its antiinflammatory effects. |
| 巻・号 | 63(7) |
| ページ | 1064-73 |
| 公開日 | 2011-1-1 |
| DOI | 10.1080/01635581.2011.596643 |
| PMID | 21864060 |
| MeSH | Animals Anti-Inflammatory Agents / pharmacology Benzopyrans / pharmacology* Cell Line Chemokines / genetics Chemokines / metabolism Gene Expression Profiling Gene Expression Regulation / drug effects* Interferons / genetics Interferons / metabolism Interleukins / genetics Interleukins / metabolism Lipopolysaccharides / adverse effects Macrophages / cytology Macrophages / drug effects* Macrophages / metabolism Mice Oligonucleotide Array Sequence Analysis* Phenols / pharmacology* Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction Signal Transduction Tea / chemistry* |
| IF | 2.363 |
| 引用数 | 6 |
| WOS 分野 | NUTRITION & DIETETICS ONCOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | RAW 264(RCB0535) |