| RRC ID |
18555
|
| Author |
Du G, Kataoka K, Sakaguchi M, Abarzua F, Than SS, Sonegawa H, Makino T, Shimizu T, Huh NH.
|
| Title |
Expression of REIC/Dkk-3 in normal and hyperproliferative epidermis.
|
| Journal |
Exp Dermatol
|
| Abstract |
Dickkopf (Dkk) family members are known as Wnt modulators involved in the development, cell growth/differentiation and cancer. REIC/Dkk-3, which does not interfere with Wnt signalling, has been proposed to be a tumor suppressor gene, but its physiological function has remained unclear. In this study, we analysed the expression of REIC/Dkk-3 in normal interfollicular epidermis (IFE) and hyperproliferative epidermis. REIC/Dkk-3 was expressed in human and mouse IFE, being localized at the interface of upper spinous layer and granular layer. Skin cancer cell lines lost REIC/Dkk-3 expression as reported previously. When we analysed patient samples, REIC/Dkk-3 expression was down-regulated in the hyperproliferative epidermis including skin cancers and non-cancerous proliferative diseases. REIC/Dkk-3 expression was also suppressed in the regenerative and inflammative epidermis of model mice. These findings will certainly contribute to the extension of studies on REIC/Dkk-3.
|
| Volume |
20(3)
|
| Pages |
273-7
|
| Published |
2011-3-1
|
| DOI |
10.1111/j.1600-0625.2010.01244.x
|
| PMID |
21323747
|
| MeSH |
Adaptor Proteins, Signal Transducing
Animals
Cell Line, Tumor
Chemokines
Down-Regulation / physiology
Embryo, Mammalian / metabolism
Epidermis / embryology
Epidermis / metabolism*
Hair Follicle / metabolism
Humans
Inflammation / chemically induced
Inflammation / metabolism
Intercellular Signaling Peptides and Proteins / metabolism*
Keratosis / metabolism*
Male
Mice
Mice, Inbred BALB C
Skin Diseases, Papulosquamous / metabolism*
Skin Neoplasms / metabolism*
Tetradecanoylphorbol Acetate / pharmacology
Wound Healing / physiology
|
| IF |
3.368
|
| Times Cited |
11
|
|
WOS Category
|
DERMATOLOGY
|
| Resource |
| Human and Animal Cells |
BSCC-93(RCB1202) |
