論文 - 詳細
| RRC ID | 18575 |
|---|---|
| 著者 | Bader RA, Silvers AL, Zhang N. |
| タイトル | Polysialic acid-based micelles for encapsulation of hydrophobic drugs. |
| ジャーナル | Biomacromolecules |
| Abstract |
Despite improvements relative to unmodified counterparts, poly(ethylene glycol) (PEG) conjugation may not be the ideal solution for improving circulatory stability of current nanoparticle carriers or free drugs. Polysialic acid (PSA), a natural polymer for which the body possesses no receptors, has been conjugated directly to biologically active molecules to prevent premature clearance; however, this concept has not yet been applied to nanoparticle drug carrier systems. In the current study, PSA was modified with a long-chain hydrocarbon through reaction of the carboxylic acid side groups with N-decylamine (DA). The resultant PSA-DA conjugates self-assembled into micelles for encapsulation of hydrophobic drug molecules, as demonstrated with Cyclosporine A. Cytotoxicty was dependent on the degree of substitution with DA. On the basis of size and zeta potential, the micelles are capable of passively targeting diseased regions, such as cancer and inflammatory tissue. Further investigations are necessary to explore whether the PSA-based micelles possess stealth properties similar to those of PEG and to establish in vitro and in vivo efficacy. |
| 巻・号 | 12(2) |
| ページ | 314-20 |
| 公開日 | 2011-2-14 |
| DOI | 10.1021/bm1008603 |
| PMID | 21218771 |
| MeSH | Amines / chemistry Amines / pharmacology Carboxylic Acids / chemistry Cell Line Cyclosporine / chemistry* Drug Carriers / chemical synthesis Drug Carriers / chemistry* Fibroblasts / drug effects Humans Hydrophobic and Hydrophilic Interactions Micelles* Molecular Structure Particle Size Sialic Acids / chemical synthesis Sialic Acids / chemistry* Structure-Activity Relationship |
| IF | 6.092 |
| 引用数 | 61 |
| WOS 分野 | POLYMER SCIENCE CHEMISTRY, ORGANIC BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 12 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | MH7A(RCB1512) |