| RRC ID |
18589
|
| Author |
Tagaya M, Yamazaki T, Tsuya D, Sugimoto Y, Hanagata N, Ikoma T.
|
| Title |
Nano/microstructural effect of hydroxyapatite nanocrystals on hepatocyte cell aggregation and adhesion.
|
| Journal |
Macromol Biosci
|
| Abstract |
Hepatocyte cell aggregation and adhesion to HAp nanocrystals covered with SU-8 polymer micropatterns by nano/microfabrication techniques is demonstrated. The surface roughness and wettability of the HAp nanocrystals are significantly different from those of the SU-8 polymer. QCM-D and microscopic observation clearly reveal that the cells realize the surface properties to form aggregation and preferentially adhere to the HAp nanocrystals at 2 h after seeding, indicating the importance of the microstructures as well as the interfacial phenomena at a nanometer scale.
|
| Volume |
11(11)
|
| Pages |
1586-93
|
| Published |
2011-11-10
|
| DOI |
10.1002/mabi.201100182
|
| PMID |
22052565
|
| MeSH |
Biocompatible Materials / chemical synthesis*
Biocompatible Materials / metabolism
Biocompatible Materials / pharmacology
Cell Adhesion
Cell Aggregation
Crystallography, X-Ray
Durapatite / chemistry
Durapatite / metabolism*
Durapatite / pharmacology
Epoxy Compounds / chemistry
Hepatocytes / drug effects
Hepatocytes / physiology*
Humans
Microscopy, Atomic Force
Nanoparticles / chemistry
Nanoparticles / ultrastructure
Particle Size
Photochemical Processes
Surface Properties
Tissue Engineering / methods*
Tumor Cells, Cultured
|
| IF |
3.416
|
| Times Cited |
13
|
|
WOS Category
|
POLYMER SCIENCE
BIOCHEMISTRY & MOLECULAR BIOLOGY
MATERIALS SCIENCE, BIOMATERIALS
|
| Resource |
| Human and Animal Cells |
Hep G2 (RCB1648) |
