RRC ID 18615
Author Seki T, Kokuryo T, Yokoyama Y, Suzuki H, Itatsu K, Nakagawa A, Mizutani T, Miyake T, Uno M, Yamauchi K, Nagino M.
Title Antitumor effects of α-bisabolol against pancreatic cancer.
Journal Cancer Sci.
Abstract In the present study, we investigated whether α-bisabolol, a sesquiterpene alcohol present in essential oils derived from a variety of plants, has antitumor effects against pancreatic cancer. α-Bisabolol induced a decrease in cell proliferation and viability in pancreatic cancer cell lines (KLM1, KP4, Panc1, MIA Paca2), but not in pancreatic epithelial cells (ACBRI515). α-Bisabolol treatment induced apoptosis and suppressed Akt activation in pancreatic cancer cell lines. Furthermore, α-bisabolol treatment induced the overexpression of early growth response-1 (EGR1), whereas EGR1 siRNA decreased the α-bisabolol-induced cell death of KLM1 cells. Tumor growth in both subcutaneous and peritoneal xenograft nude mouse models was significantly inhibited by intragastric administration of 1000 mg/kg of α-bisabolol, once a week for three weeks. The results indicate that α-bisabolol could be a novel therapeutic option for the treatment of pancreatic cancer.
Volume 102(12)
Pages 2199-205
Published 2011-12
DOI 10.1111/j.1349-7006.2011.02082.x
PMID 21883695
MeSH Animals Apoptosis / drug effects Cell Line, Tumor Cell Proliferation / drug effects Cell Survival / drug effects Early Growth Response Protein 1 / metabolism* Epithelial Cells / drug effects Humans Mice Mice, Inbred BALB C Mice, Nude Pancreatic Neoplasms / drug therapy Pancreatic Neoplasms / metabolism Pancreatic Neoplasms / pathology Plant Oils / administration & dosage Plant Oils / pharmacology Proto-Oncogene Proteins c-akt / metabolism RNA Interference RNA, Small Interfering Sesquiterpenes / administration & dosage Sesquiterpenes / pharmacology* Xenograft Model Antitumor Assays
IF 4.372
Times Cited 14
Human and Animal Cells MIA Paca2 (RCB2094) KP4 (RCB1005)