論文 - 詳細
| RRC ID | 18615 |
|---|---|
| 著者 | Seki T, Kokuryo T, Yokoyama Y, Suzuki H, Itatsu K, Nakagawa A, Mizutani T, Miyake T, Uno M, Yamauchi K, Nagino M. |
| タイトル | Antitumor effects of α-bisabolol against pancreatic cancer. |
| ジャーナル | Cancer Sci |
| Abstract |
In the present study, we investigated whether α-bisabolol, a sesquiterpene alcohol present in essential oils derived from a variety of plants, has antitumor effects against pancreatic cancer. α-Bisabolol induced a decrease in cell proliferation and viability in pancreatic cancer cell lines (KLM1, KP4, Panc1, MIA Paca2), but not in pancreatic epithelial cells (ACBRI515). α-Bisabolol treatment induced apoptosis and suppressed Akt activation in pancreatic cancer cell lines. Furthermore, α-bisabolol treatment induced the overexpression of early growth response-1 (EGR1), whereas EGR1 siRNA decreased the α-bisabolol-induced cell death of KLM1 cells. Tumor growth in both subcutaneous and peritoneal xenograft nude mouse models was significantly inhibited by intragastric administration of 1000 mg/kg of α-bisabolol, once a week for three weeks. The results indicate that α-bisabolol could be a novel therapeutic option for the treatment of pancreatic cancer. |
| 巻・号 | 102(12) |
| ページ | 2199-205 |
| 公開日 | 2011-12-1 |
| DOI | 10.1111/j.1349-7006.2011.02082.x |
| PMID | 21883695 |
| MeSH | Animals Apoptosis / drug effects Cell Line, Tumor Cell Proliferation / drug effects Cell Survival / drug effects Early Growth Response Protein 1 / metabolism* Epithelial Cells / drug effects Humans Mice Mice, Inbred BALB C Mice, Nude Monocyclic Sesquiterpenes Pancreatic Neoplasms / drug therapy Pancreatic Neoplasms / metabolism Pancreatic Neoplasms / pathology Plant Oils / administration & dosage Plant Oils / pharmacology Proto-Oncogene Proteins c-akt / metabolism RNA Interference RNA, Small Interfering Sesquiterpenes / administration & dosage Sesquiterpenes / pharmacology* Xenograft Model Antitumor Assays |
| IF | 4.966 |
| 引用数 | 30 |
| WOS 分野 | ONCOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 10 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | MIA Paca2(RCB2094) KP4(RCB1005) |