Reference - Detail
| RRC ID | 18698 |
|---|---|
| Author | Sugiyama K, Muroi M, Tanamoto K, Nishijima M, Sugita-Konishi Y. |
| Title | Deoxynivalenol and nivalenol inhibit lipopolysaccharide-induced nitric oxide production by mouse macrophage cells. |
| Journal | Toxicol Lett |
| Abstract |
Deoxynivalenol (DON) and nivalenol (NIV), trichothecene mycotoxins, are secondary metabolites produced by Fusarium fungi. Trichothecene mycotoxins cause immune dysfunction, thus leading to diverse responses to infection. The present study evaluated the effect of DON and NIV on nitric oxide (NO) production by RAW264 cells stimulated with lipopolysaccharide (LPS). LPS-induced NO production was reduced in the presence of these toxins. The transcriptional activation and expression of inducible NO synthase (iNOS) by LPS were also repressed by these toxins. DON or NIV inhibited LPS-induced expression of interferon-beta (IFN-beta), which plays an indispensable role in LPS-induced iNOS expression. These results indicate that DON and NIV inhibit the LPS-induced NO and IFN-beta production, which both play an important role for host protection against invading pathogens, and suggests that the inhibition of these factors may be involved in the immunotoxic effects of these mycotoxins. |
| Volume | 192(2) |
| Pages | 150-4 |
| Published | 2010-2-1 |
| DOI | 10.1016/j.toxlet.2009.10.020 |
| PII | S0378-4274(09)01475-1 |
| PMID | 19857559 |
| MeSH | Animals Cell Line Fusarium / pathogenicity Interferon-beta / metabolism Lipopolysaccharides / antagonists & inhibitors* Lipopolysaccharides / metabolism Macrophages / drug effects Macrophages / immunology Macrophages / metabolism* Mice Mycotoxins / toxicity* Nitric Oxide / metabolism* Nitric Oxide Synthase / genetics Nitric Oxide Synthase / metabolism Trichothecenes / toxicity* |
| IF | 3.569 |
| Times Cited | 20 |
| WOS Category | TOXICOLOGY |
| Altmetric score |
オルトメトリクス指標項目
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| Total number of mentions | 0 |
| Resource | |
| Human and Animal Cells | RAW 264(RCB0535) |