Reference - Detail
| RRC ID | 18891 |
|---|---|
| Author | Imazato S, Horikawa D, Takeda K, Kiba W, Izutani N, Yoshikawa R, Hayashi M, Ebisu S, Nakano T. |
| Title | Proliferation and differentiation potential of pluripotent mesenchymal precursor C2C12 cells on resin-based restorative materials. |
| Journal | Dent Mater J |
| Abstract |
This study investigated the proliferation and differentiation potential of pluripotent mesenchymal cells on three resin-based restoratives using a typical pluripotent mesenchymal precursor cell line, C2C12. C2C12 cells were cultured for 3-21 days on cured specimens of a Bis-GMA/TEGDMA-based composite resin (APX; Clearfil AP-X), a 4-META/MMA-based resin cement (SB; Superbond C&B) or a HEMA-containing resin modified glass-ionomer (LC; Fuji Ionomer Type II LC). To examine the influences on differentiation potential, alkaline phosphatase (ALP) activity of the cells cultured on each material was determined. On APX and SB, cells adhered and proliferated well, and no significant influences on ALP activity were observed. In contrast, poor cell proliferation and significant suppression of ALP activity were observed for cells cultured on LC, similar to those cultured on a zinc oxide EBA cement used as a control material. Bis-GMA/TEGDMA-based composite resin and 4-META/MMA-based resin exhibited better biocompatibility for C2C12 cells than HEMA-containing resin modified glass-ionomer, suggesting a potential advantage of the former two resins to show smaller influences on regeneration of periapical or periodontal tissue. |
| Volume | 29(3) |
| Pages | 341-6 |
| Published | 2010-5-1 |
| DOI | 10.4012/dmj.2009-082 |
| PII | JST.JSTAGE/dmj/2009-082 |
| PMID | 20467157 |
| MeSH | Alkaline Phosphatase / biosynthesis Animals Cell Adhesion Cell Differentiation Cell Line Cell Proliferation Composite Resins* Dental Restoration, Permanent Glass Ionomer Cements* Hydroxybenzoate Ethers Hydroxybenzoates Mesenchymal Stem Cells / cytology* Mice Mice, Inbred C3H Pluripotent Stem Cells / cytology* Regeneration Resin Cements* Tetrazolium Salts / metabolism Thiazoles / metabolism Tissue Scaffolds* Zinc Oxide-Eugenol Cement / chemistry |
| IF | 1.359 |
| Times Cited | 15 |
| WOS Category | DENTISTRY, ORAL SURGERY & MEDICINE MATERIALS SCIENCE, BIOMATERIALS |
| Altmetric score |
オルトメトリクス指標項目
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| Total number of mentions | 0 |
| Resource | |
| Human and Animal Cells | C2C12(RCB0987) |