論文 - 詳細
| RRC ID | 18891 |
|---|---|
| 著者 | Imazato S, Horikawa D, Takeda K, Kiba W, Izutani N, Yoshikawa R, Hayashi M, Ebisu S, Nakano T. |
| タイトル | Proliferation and differentiation potential of pluripotent mesenchymal precursor C2C12 cells on resin-based restorative materials. |
| ジャーナル | Dent Mater J |
| Abstract |
This study investigated the proliferation and differentiation potential of pluripotent mesenchymal cells on three resin-based restoratives using a typical pluripotent mesenchymal precursor cell line, C2C12. C2C12 cells were cultured for 3-21 days on cured specimens of a Bis-GMA/TEGDMA-based composite resin (APX; Clearfil AP-X), a 4-META/MMA-based resin cement (SB; Superbond C&B) or a HEMA-containing resin modified glass-ionomer (LC; Fuji Ionomer Type II LC). To examine the influences on differentiation potential, alkaline phosphatase (ALP) activity of the cells cultured on each material was determined. On APX and SB, cells adhered and proliferated well, and no significant influences on ALP activity were observed. In contrast, poor cell proliferation and significant suppression of ALP activity were observed for cells cultured on LC, similar to those cultured on a zinc oxide EBA cement used as a control material. Bis-GMA/TEGDMA-based composite resin and 4-META/MMA-based resin exhibited better biocompatibility for C2C12 cells than HEMA-containing resin modified glass-ionomer, suggesting a potential advantage of the former two resins to show smaller influences on regeneration of periapical or periodontal tissue. |
| 巻・号 | 29(3) |
| ページ | 341-6 |
| 公開日 | 2010-5-1 |
| DOI | 10.4012/dmj.2009-082 |
| PII | JST.JSTAGE/dmj/2009-082 |
| PMID | 20467157 |
| MeSH | Alkaline Phosphatase / biosynthesis Animals Cell Adhesion Cell Differentiation Cell Line Cell Proliferation Composite Resins* Dental Restoration, Permanent Glass Ionomer Cements* Hydroxybenzoate Ethers Hydroxybenzoates Mesenchymal Stem Cells / cytology* Mice Mice, Inbred C3H Pluripotent Stem Cells / cytology* Regeneration Resin Cements* Tetrazolium Salts / metabolism Thiazoles / metabolism Tissue Scaffolds* Zinc Oxide-Eugenol Cement / chemistry |
| IF | 1.359 |
| 引用数 | 15 |
| WOS 分野 | DENTISTRY, ORAL SURGERY & MEDICINE MATERIALS SCIENCE, BIOMATERIALS |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| ヒト・動物細胞 | C2C12(RCB0987) |