| RRC ID |
18895
|
| 著者 |
Kubo E, Yoshikawa N, Kunitomo M, Kagota S, Shinozuka K, Nakamura K.
|
| タイトル |
Inhibitory effect of Cordyceps sinensis on experimental hepatic metastasis of melanoma by suppressing tumor cell invasion.
|
| ジャーナル |
Anticancer Res
|
| Abstract |
We investigated the anti-metastatic activity of a water extract of Cordyceps sinensis (WECS) using a model of mice injected with B16-F0 mouse melanoma cells into the spleen. WECS administered intraperitoneally reduced the number of metastatic surface nodules of B16-F0 cells in the liver of C57BL/6Cr mice in a dose-dependent manner, and significantly prolonged their survival. To identify the mechanism of the anti-metastatic effect of WECS, we examined its effects on hepatocyte growth factor (HGF)-accelerated invasion of B16-F0 cells using a chemo-invasion assay in vitro. As a result, WECS reduced HGF-accelerated B16-F0 cell invasion in a concentration-dependent manner. These findings suggest that WECS exerts an anti-metastatic action, in part by inhibiting the HGF-accelerated tumor invasiveness of mouse melanoma cells.
|
| 巻・号 |
30(9)
|
| ページ |
3429-33
|
| 公開日 |
2010-9-1
|
| PII |
30/9/3429
|
| PMID |
20944118
|
| MeSH |
Animals
Antineoplastic Agents / pharmacology*
Cordyceps / chemistry*
Female
Hepatocyte Growth Factor
Liver Neoplasms / drug therapy*
Liver Neoplasms / secondary*
Melanoma, Experimental / secondary*
Mice
Mice, Inbred C57BL
Neoplasm Invasiveness / pathology*
|
| IF |
1.994
|
| 引用数 |
15
|
|
WOS 分野
|
ONCOLOGY
|
| リソース情報 |
| ヒト・動物細胞 |
C57BL/6J-emb(RCB1312) |
