論文 - 詳細
| RRC ID | 18942 |
|---|---|
| 著者 | Takebayashi J, Ishii R, Chen J, Matsumoto T, Ishimi Y, Tai A. |
| タイトル | Reassessment of antioxidant activity of arbutin: multifaceted evaluation using five antioxidant assay systems. |
| ジャーナル | Free Radic Res |
| Abstract |
Arbutin, a practically used skin-lightening agent, has been reported to possess a weak antioxidant activity compared to that of its precursor, hydroquinone. However, its antioxidant activity has not been systematically evaluated. Hence, this study reassessed its activity using five assay systems. Assays were first performed using model radicals, DPPH radical and ABTS(*+). Arbutin showed weak DPPH radical-scavenging activity compared to that of hydroquinone, but showed strong ABTS(*+)-scavenging activity. Its activity by ORAC assay was then evaluated using a physiologically relevant peroxyl radical. Arbutin exerted weak but long-lasting radical-scavenging activity and showed totally the same antioxidant activity as that of hydroquinone. Finally, it was shown that, in two cell-based antioxidant assays using erythrocytes and skin fibroblasts, arbutin exerted strong antioxidant activity comparable or even superior to that of hydroquinone. These findings indicate that the antioxidant activity of arbutin may have been under-estimated and suggest that it acts as a potent antioxidant in the skin. |
| 巻・号 | 44(4) |
| ページ | 473-8 |
| 公開日 | 2010-4-1 |
| DOI | 10.3109/10715761003610760 |
| PMID | 20166881 |
| MeSH | Animals Antioxidants / chemistry Antioxidants / pharmacology* Arbutin / chemistry Arbutin / pharmacology* Benzothiazoles Biphenyl Compounds / chemistry Cell Survival / drug effects Cells, Cultured Dose-Response Relationship, Drug Erythrocytes / drug effects Erythrocytes / metabolism Fibroblasts / drug effects Fibroblasts / metabolism Hemolysis / drug effects Humans Hydroquinones / chemistry Oxidative Stress / drug effects* Picrates / chemistry Sheep Structure-Activity Relationship Sulfonic Acids / chemistry Thiazoles / chemistry Time Factors |
| IF | 2.839 |
| 引用数 | 44 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| ヒト・動物細胞 | NB1RGB(RCB0222) |