Reference - Detail
| RRC ID | 1914 |
|---|---|
| Author | Kumano Y, Sakamoto T, Egawa M, Iwai I, Tanaka M, Yamamoto I. |
| Title | In vitro and in vivo prolonged biological activities of novel vitamin C derivative, 2-O-alpha-D-glucopyranosyl-L-ascorbic acid (AA-2G), in cosmetic fields. |
| Journal | J Nutr Sci Vitaminol (Tokyo) |
| Abstract |
The biological activity of the novel vitamin C derivative, 2-O-alpha-D-glucopyranosyl-L-ascorbic acid (AA-2G), was evaluated in vitro and in vivo. The percutaneous absorption of AA-2G was determined in five Japanese males. The excretion of ascorbic acid (AA) in the subjects administered AA-2G was sustained for a longer period than in the subjects administered ascorbic acid 2-phosphate (AA-2P), which is a conventional vitamin C derivative. An analysis of the distribution of AA in the skin showed that small black specks assumed to be AA were observed in the epidermis even 3 d after applying AA-2G. The melanin synthesis in B16 melanoma cells was inhibited more by AA-2G than by AA-2P, and AA-2G also prevented more UV-induced damage of human skin keratinocytes and fibroblasts than AA-2P did. From these in vivo and in vitro results, it is supposed that the conversion of AA-2G to AA is sustained for a long time compared with that of AA-2P, and that AA-2G is an effective and available compound having vitamin C activity in human subjects. |
| Volume | 44(3) |
| Pages | 345-59 |
| Published | 1998-6-1 |
| DOI | 10.3177/jnsv.44.345 |
| PMID | 9742456 |
| MeSH | Absorption Ascorbic Acid / analogs & derivatives* Ascorbic Acid / analysis Ascorbic Acid / metabolism Ascorbic Acid / pharmacokinetics Ascorbic Acid / pharmacology Ascorbic Acid / therapeutic use Cells, Cultured Cosmetics* Epidermis / metabolism Humans Hydroxyl Radical / metabolism Keratinocytes / drug effects Keratinocytes / radiation effects Lipid Peroxidation / drug effects Male Melanins / biosynthesis Melanoma / metabolism Skin / chemistry Skin / metabolism Sunburn / prevention & control Tissue Distribution Tumor Cells, Cultured Ultraviolet Rays |
| IF | 1.424 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Patent(IFI CLAIMS) |
| Total number of mentions | 2 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | NB1RGB(RCB0222) |